Publications by authors named "Peter Mendik"
Regulation of translocating proteins is crucial in defining cellular behaviour. Epithelial-mesenchymal transition (EMT) is important in cellular processes, such as cancer progression. Several orchestrators of EMT, such as key transcription factors, are known to translocate.
View Article and Find Full Text PDFMolecular processes of neuronal learning have been well described. However, learning mechanisms of non-neuronal cells are not yet fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins (IDPs) and prions, signaling cascades, protein translocation, RNAs [miRNA and long noncoding RNA (lncRNA)], and chromatin memory.
View Article and Find Full Text PDFArticle Synopsis
- - Translocatome is a new database focused on human translocating proteins, featuring a curated list of 213 proteins along with their experimental validation sources, translocation mechanisms, and roles in diseases and signaling pathways.
- - The database employs XGBoost machine learning to predict translocation probabilities for over 13,000 proteins, identifying high-confidence and low-confidence translocating proteins.
- - With user-friendly search features and downloadable data sets, Translocatome enables researchers to explore protein translocation comprehensively, aiding in the study of this biological phenomenon.