Interaction of Vitamin D-BODIPY With Fat Cells and the Link to Obesity-associated Vitamin D Deficiency.

Background/aim: Obese individuals often exhibit vitamin D deficiency, potentially due to sequestration in fat cells. Little is known about how vitamin D enters adipocytes and associates with the intracellular lipid droplet.

Materials And Methods: Newly differentiated human and mouse (3T3-L1) adipocytes and primary mouse adipocytes were treated with vitamin D covalently linked to green fluorescent BODIPY (VitD-B) or Green BODIPY (GB) as control.

Evaluation of 14-day Concentration-time Curves of Vitamin D and 25-Hydroxyvitamin D in Healthy Adults With Varying Body Mass Index.

Background/aim: To analyze the concentration-time curves of single-dose oral 25(OH)D in comparison with vitamin D in healthy adults.

Patients And Methods: The pharmacokinetics observed over two weeks after orally administering single 900 μg doses of vitamin D and 25(OH)D to six otherwise healthy vitamin D insufficient/deficient adults participating in a broader randomized, double-blind, crossover, single center trial was analyzed. The study protocol was approved by the institutional review board (H-37167).