Publications by authors named "Peter Lazarakis"
Article Synopsis
- Gold nanoparticles enhance the effectiveness of x-ray radiotherapy in cancer treatment by improving dose delivery to tumor cells.
- Monte Carlo simulations, specifically using Geant4-DNA and advanced track structure models, help to analyze how nanoparticle distribution affects dose enhancement at the nanoscale.
- The study's findings integrate simulated dose calculations with experimental data on brain cancer cell survival, demonstrating the potential of these models for predicting treatment outcomes in radiobiology.
Purpose: The purpose of this article is to present the first imaging experiments to demonstrate the functional equivalence between a conventional rotational gantry and a fixed-beam imaging geometry, and the feasibility of an iterative image-reconstruction technique under gravitational deformation.
Methods And Materials: Experiments were performed using an Elekta Axesse with Agility MLC and XVI, a custom-built rotating phantom stage, a Catphan QA phantom, and a porcine heart. For the imaging equivalence, a conventional cone beam computed tomography (CBCT) of the Catphan was acquired, as well as a set of 660 x-ray projections with a static gantry and rotating Catphan.
Purpose: With the advent of magnetic resonance imaging (MRI)-guided radiation therapy it is becoming increasingly important to consider the potential influence of a magnetic field on ionising radiation. This paper aims to study the effect of a magnetic field on the track structure of radiation to determine if the biological effectiveness may be altered.
Methods: Using the Geant4-DNA (GEometry ANd Tracking 4) Monte Carlo simulation toolkit, nanodosimetric track structure parameters were calculated for electrons, protons and alpha particles moving in transverse magnetic fields up to 10 Tesla.