Unlocking mitochondrial dysfunction-associated senescence (MiDAS) with NAD - A Boolean model of mitochondrial dynamics and cell cycle control.

The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, including cytokines, growth and transforming signals.

Unlocking Mitochondrial Dysfunction-Associated Senescence (MiDAS) with NAD - a Boolean Model of Mitochondrial Dynamics and Cell Cycle Control.

Unlabelled: The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, including cytokines, growth and transforming signals.