Prospective intra-individual blinded comparison of [F]PSMA-1007 and [ Ga]Ga-PSMA-11 PET/CT imaging in patients with confirmed prostate cancer.

Introduction: [F]PSMA-1007 has potential advantages over [ Ga]Ga-PSMA-11, although limited prospective data evaluating diagnostic performance exist. The aims of this study are to describe the concordance of [FPSMA-1007 and [ Ga]Ga-PSMA-11 for TNM with the American Joint Committee on Cancer (AJCC) prognostic stage and assess differences in tracer uptake.

Methods: Fifty men (mean age 71.

Clinical insignificance of [F]PSMA-1007 avid non-specific bone lesions: a retrospective evaluation.

Purpose: [F]PSMA-1007 offers advantages of low urinary tracer excretion and theoretical improved spatial resolution for imaging prostate cancer. However, non-specific bone lesions (NSBLs), defined as mild to moderate focal bone uptake without a typical morphological correlate on CT, are a common finding on [F]PSMA-1007 PET/CT. The purpose of this study was to investigate the clinical outcomes of patients with [F]PSMA-1007 avid NSBLs, to determine whether patients with NSBLs represent a higher risk clinical cohort, and to determine whether SUVmax can be used as a classifier of bone metastasis.