Publications by authors named "Peter Kubesch"
Article Synopsis
- Management of cystic fibrosis (CF) relies on understanding the patient's microbiological status, particularly through evaluating anti-Pseudomonas aeruginosa antibodies, but diversity in bacterial antigens complicates measurement of infection severity.
- Researchers developed an ELISA test to specifically measure IgG antibody levels against P. aeruginosa porin OprF, allowing for better monitoring of infection status in CF patients.
- Analysis of serum samples from 310 CF patients revealed that those with chronic colonization had significantly higher OprF antibody levels compared to those with intermittent colonization, highlighting the test's utility in tracking infection progression and treatment effectiveness.
Microevolution of closely related Pseudomonas aeruginosa was compared in the clone TB strains TBCF10839 and TBCF121838 which had been isolated from two unrelated individuals with cystic fibrosis who had acquired clone TB during a local outbreak. Compared with the strain PAO1 reference sequence the two clone TB genomes shared 23 155 nucleotide exchanges, 32 out-of-frame indels in the coding region and another repertoire of replacement and genomic islands such as PAGI-1, PAGI-2, PAGI-5, LESGI-1 and LES-prophage 4. Only TBCF121838 carried a genomic island known from Ralstonia pickettii.
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