Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study.

In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner.

Flavour physics as a window to new physics searches.

Flavour physics is one of the essential elements of the Standard Model (SM). Experimental studies of weak decays of [Formula: see text] and [Formula: see text] mesons at [Formula: see text] factories have, together with the discovery of the Higgs boson at LHC, provided the final confirmation of the validity of the SM. The present generation of precision flavour physics experiments is looking for departures from the SM.

Resistance and Strength of Conductive PLA Processed by FDM Additive Manufacturing.

There is a large number of materials that can be used for FDM additive manufacturing technology. These materials have different strength properties, they are designed for different purposes. They can be highly strong or flexible, abrasion-resistant, or designed for example for environments with higher thermal loads.

Roadmap toward the 10 ps time-of-flight PET challenge.

Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with an unprecedented sensitivity at the picomolar level, especially for cancer diagnosis and the monitoring of its response to therapy. More recently, its combination with x-ray computed tomography (CT) or magnetic resonance (MR) has added high precision anatomic information in fused PET/CT and PET/MR images, thus compensating for the modest intrinsic spatial resolution of PET. Nevertheless, a number of medical challenges call for further improvements in PET sensitivity.

Simulation study to improve the performance of a whole-body PbF Cherenkov TOF-PET scanner.

Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF) crystals were used instead of a scintillator. In this work, a whole-body PbF Cherenkov TOF-PET scanner was simulated and optimized.

Novel MLH1 and MSH2 germline mutations in the first HNPCC families identified in Slovakia.

Hereditary nonpolyposis colorectal cancer (HNPCC) is a dominantly-inherited cancer predisposition syndrome, in which the susceptibility to cancer of the colon, endometrium and ovary is linked to germline mutations in DNA mismatch repair (MMR) genes. We have recently initiated a cancer prevention program in suspected HNPCC families in the Slovak Republic. The first ten families fulfilling Amsterdam criteria or Bethesda guidelines were screened for germline mutations in MLH1 and MSH2, two MMR genes most frequently mutated in HNPCC families.