Publications by authors named "Peter Kothy"
Background: For clinical practice it is important to evaluate and compare anxiety, depression and quality of life of glaucoma patients with painless one-eye blindness and a normal fellow eye to unaffected age-matched individuals from a similar environment.
Methods: Twenty-eight stable glaucoma patients (age, mean ± SD: 69.0 ± 13.
In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina.
View Article and Find Full Text PDFIntroduction: A non-interventional, multicenter, European, prospective evaluation of the effectiveness, tolerability, and safety of a topical preservative-free tafluprost (0.0015%) and timolol (0.5%) fixed-dose combination (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) and ocular hypertension (OHT) demonstrating insufficient response to topical beta-receptor blockers or prostaglandin analogue (PGA) monotherapy.
View Article and Find Full Text PDFPurpose: To investigate the intraocular pressure (IOP)-lowering efficacy and tolerance of brinzolamide/brimonidine fixed combination (BBFC) under real-life conditions in a tertiary glaucoma centre.
Methods: Medical records of all ocular hypertensive and open-angle glaucoma patients (n = 52) treated with BBFC were retrospectively analysed.
Results: Thirty-nine patients had primary open-angle, 6 exfoliative, 2 pigment, 1 normal tension and 1 juvenile open-angle glaucoma and 3 ocular hypertension.
Background: To investigate the outcomes of glaucoma referrals across different European countries.
Methods: 250 patients newly referred to tertiary referral glaucoma specialist practices in the UK, Hungary, Slovenia, Italy and Greece were prospectively enrolled (50 consecutive patients per centre). Referral accuracy and predictive value of referral criteria for an intervention or further monitoring (positive predictive value) were analysed.
Purpose: To present a case of topical prostaglandin analogue-induced skin pigmentation in a location previously never reported, with a differential diagnostic significance.
Case Report: An 83-year-old man successfully treated for primary open-angle glaucoma of both eyes with the bimatoprost/timolol fixed combination for 6 years reported increased pigmentation of the skin of the nasal septum and alae. According to his report, the darkened skin area was not present when he was a young or middle-aged man.
Purpose: To evaluate 24-hour continuous intraocular pressure (IOP) monitoring with a telemetric contact lens sensor (CLS) to detect prostaglandin-induced IOP reduction.
Methods: In this prospective interventional study 9 ocular hypertensive and primary open-angle glaucoma patients were washed out from IOP-lowering medication for 6 weeks. One study eye per patient underwent 3 baseline 24-hour measurement curves 4 days apart: 2 curves with Sensimed Triggerfish CLS and 1 curve with Goldmann applanation tonometry (GAT).
Purpose: To evaluate exfoliative glaucoma (XFG) patients over 5 years, determining risk factors associated with progression or non-progression of glaucoma.
Methods: A retrospective, observational study. Patients were chosen from consecutive charts and data collected from each available visit included in the follow-up period.
Purpose: To present a case with co-existence of Cogan-Reese syndrome and exfoliation syndrome.
Case Report: A 72-year-old Caucasian woman presented for consultation due to uncontrolled intraocular pressure (IOP) of the right eye. Clinical examination revealed the presence of Cogan-Reese syndrome and exfoliation syndrome OD.
Purpose: To determine the direct costs of therapy over 5 years of a European monotherapy cohort begun on a prostaglandin (PTG) versus timolol in patients with primary open-angle glaucoma or ocular hypertension.
Methods: A retrospective, multicenter, active-controlled, observational study. Data were abstracted for European patients treated as initial monotherapy in 1996 or afterward, with 5 years of available records.
Purpose: To investigate whether osteoporosis patient organization members with advanced health awareness can identify their risk for glaucoma.
Methods: Members of an osteoporosis patient organization group were provided with structured written information on risk factors for glaucoma. Later, the participants completed questionnaires on their risk for glaucoma (average vs.
The aim of this study was to evaluate the usefulness of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-100 OCT) in screening for glaucoma and non-arteritic anterior ischemic optic neuropathy (NA-AION). In a non-population-based pre-publicised trial, self-recruited Caucasian participants were screened for glaucoma and NA-AION using the RTVue-100 OCT, and also by independent clinical examination. For the RTVue-100 OCT measurements, the optic nerve head (ONH) scan and the macular ganglion cell complex (GCC) scan were applied.
View Article and Find Full Text PDFPurpose: To investigate if patients with exfoliation glaucoma (XFG) with cardiovascular disease (CVD) require different target intraocular pressure (IOP) compared to patients with XFG with no CVD for long-term stability.
Methods: A retrospective, multicenter, observational cohort analysis included consecutive patients with XFG from 9 European academic centers, with a minimum of 5 years follow-up.
Results: In 201 patients, there was a statistical difference between progressed and non-progressed patients in mean (p=0.
Background And Objective: To investigate the influence of selective laser trabeculoplasty on mean diurnal intraocular pressure (IOP) and diurnal IOP fluctuation in primary open-angle glaucoma.
Patients And Methods: After washout from intraocular pressure-lowering drugs, a baseline diurnal IOP curve was obtained for 26 eyes of 13 patients before selective laser trabeculoplasty. The IOP curve was repeated at 3 and 6 months.
Purpose: To investigate whether the single nucleotide polymorphisms (SNPs) of the LOXL1 gene associated with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) are different in XFS/XFG patients with and without cardiovascular disease (CVD); and to compare the allele frequencies in XFS/XFG with those in ischemic cerebrovascular disease (stroke), in the Hungarian population.
Methods: G153D and R141L allele frequencies were determined for 56 XFS/XFG patients (10 patients with and 45 without CVD, 1 patient unclassified), and for 189 patients with stroke.
Results: For G153D the frequencies of guanine (G) and adenine (A) alleles were 71.
Purpose: To investigate the influence of personality traits, depression, and training on objectively measured adherence to once-daily prostaglandin analog medication.
Methods: Adherence was measured with the Travalert Dosing Aid on 58 consecutive, regularly followed-up glaucoma patients already on self-administered travoprost. Before the 3-month data-collection period all patients received training on use of the device.
Purpose: To compare the usefulness in glaucoma screening of scanning laser polarimetry (GDx-VCC), scanning laser tomography [Heidelberg retina tomograph II (HRT II)], and their combined evaluation.
Methods: In a nonpopulation-based prepublicized trial, self-recruited white participants were screened for glaucoma with GDx-VCC, HRT II, and by independent clinical examination. Cases with possible glaucoma as found with any of the screening methods underwent a detailed clinical investigation to verify or exclude glaucoma.
Objective: To investigate if combined intraocular pressure (IOP)-lowering medication with travoprost/timolol fixed combination and a carbonic anhydrase inhibitor, brinzolamide, is superior to both travoprost monotherapy and travoprost/timolol fixed-combination therapy in primary open-angle glaucoma and ocular hypertension.
Methods: Following a 4-week wash-out period and using 4-week long treatment periods, 20 primary open-angle glaucoma or ocular hypertension patients were treated with evening travoprost 0.004%, then switched to evening travoprost 0.
Purpose: To assess the advantage in glaucoma screening of the use of scanning laser polarimetry with customized cornea compensation (GDx-VCC) combined with Matrix Frequency Doubling Technology (M-FDT) testing.
Methods: In a nonpopulation-based prepublicized trial, self-recruited white participants were screened for glaucoma with GDx-VCC, with M-FDT, and by independent clinical examination. Cases with possible glaucoma as found with any of the screening methods underwent a detailed clinical investigation to verify or exclude glaucoma.
Objective: To investigate the influence of switching to travoprost on intraocular pressure (IOP) of chronic open-angle glaucoma (COAG) patients.
Research Design And Methods: Multicentre, open-label, non-comparative, 12-week, phase IV study conducted at 10 academic and hospital centres in Hungary. Patients' compliance to use of the pre-study medication was confirmed at a visit 10 days before the baseline measurements, and compliance was monitored throughout the study period.
Background: To investigate the clinical usefulness of the Heidelberg Retina Tomograph II (HRT II) in glaucoma-screening.
Material And Methods: HRT II measurements were performed on 53 glaucomatous, 33 normal and 24 glaucoma suspect eyes. HRT II classification ("glaucoma", "borderline" and "normal") was compared to the classification of clinical examination (biomicroscopic indirect papilla examination, applanation tonometry, threshold perimetry) as well as to the classifications determined with threshold perimetry or GDx nerve fibre analysis simulating a screening examination.
Purpose: We have previously shown in rabbits that the intraocular pressure (IOP) spike caused by argon laser trabeculoplasty (ALT) is associated with an acute endothelin-1 (ET-1) release from the uveal tissue into the aqueous humour. In this study we investigated whether pretreatment with an ET(A) receptor antagonist (BQ-485) protects against the pressure spike induced by ALT, in the rabbit model.
Methods: Under general anaesthesia, 10 microl of 10(-5) M BQ-485 was injected into the anterior chamber of the right eye, and 10 microl of balanced salt solution (BSS) into the contralateral anterior chamber, for 12 pigmented rabbits.
Background: The purpose of the present study was to evaluate the clinical applicability of the Ocuton-A and Ocuton-S applanation tonometers, and to compare their use and accuracy parameters to those of Goldmann applanation tonometry (GAT).
Material/methods: In the first study, intraocular pressure (IOP) was measured with an Ocuton-A tonometer, followed by another measurement using GAT in 15 subjects (30 eyes). Ocuton-tonometry was performed on three occasions separated by three-minute intervals.