Combining Baerveldt Implant with Trabectome Negates Tube Fenestration: A Coarsened-matched Comparison.

Purpose: To assess the efficacy and survival rate of the Trabectome-mediated ab interno trabeculectomy combined with non-fenestrated Baerveldt glaucoma implant compared with the Baerveldt glaucoma implant alone.

Methods: In this retrospective comparative case series, 175 eyes undergoing primary glaucoma surgery (Baerveldt-Trabectome [BT] group: 60 eyes and Baerveldt [B] group: 115 eyes) were included. Participants were identified using the procedural terminology codes.

Strabismus resulting from an anomalous extraocular muscle in Gorlin syndrome.

Strabismus associated with anomalous extraocular muscles is rare. We present a case of strabismus caused by an anomalous orbital structure that was histopathologically consistent with an accessory extraocular muscle rather than a fibrous band, in a patient with Gorlin syndrome (nevoid basal cell carcinoma syndrome), an autosomal dominant multisystem disorder related to a mutation in the patched tumor suppressor gene (PTCH). Histopathology of an anomalous orbital structure consistent with extraocular muscle has not been previously reported.

Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos.

Background: The Runt homology domain (Runx) defines a metazoan family of sequence-specific transcriptional regulatory proteins that are critical for animal development and causally associated with a variety of mammalian cancers. The sea urchin Runx gene SpRunt-1 is expressed throughout the blastula stage embryo, and is required globally during embryogenesis for cell survival and differentiation.

Methodology/principal Findings: Depletion of SpRunt-1 by morpholino antisense-mediated knockdown causes a blastula stage deficit in cell proliferation, as shown by bromodeoxyuridine (BrdU) incorporation and direct cell counts.