Publications by authors named "Peter K Yablonsky"
Article Synopsis
- Tuberculosis (TB) is a global health issue, especially with rising drug-resistant strains and connections to HIV, yet there's a lack of a centralized resource linking TB genome data with geographic and clinical information.
- The Genome-wide Mycobacterium tuberculosis Variation (GMTV) database compiles genome variations from M. tuberculosis strains in Russia, featuring data on drug resistance, clinical outcomes, and more, accessible through an online browser.
- GMTV helps track changes in TB strains across different regions, supports research on drug resistance and clinical effects, and enhances comparisons of M. tuberculosis genomes.
Article Synopsis
- The study focuses on the Mycobacterium tuberculosis (MTB) Beijing family, specifically the B0/W148 group found in Russia, which is known for being widespread, hypervirulent, and drug-resistant.
- Researchers sequenced four clinical isolates from this group and compared their genomes to the W-148 strain to identify significant genomic features.
- They discovered two large genomic inversions in the B0/W148 strains, suggesting that such rearrangements in MTB are more common than previously thought, highlighting the need for further research into these genetic changes.
