Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: A report from the PAROKRANK study.

Aim: To explore associations between root filled teeth, primary and secondary apical periodontitis, and levels of inflammatory markers in blood from patients with a first myocardial infarction and matched controls.

Methodology: Between May 2010 and February 2014, 805 patients with a first myocardial infarction and 805 controls, matched for sex, age, and postal code area, were recruited to the multicentre case-control study PAROKRANK (periodontitis and its relation to coronary artery disease). All participants underwent a physical and oral examination, as well as blood sampling.

A Weighted Composite of Endodontic Inflammatory Disease is Linked to a First Myocardial Infarction.

Purpose: To explore a weighted composite of endodontic inflammatory disease (EID) as a risk factor for suffering a first myocardial infarction (MI).

Materials And Methods: Seven tooth-specific conditions related to EID were assessed radiographically in 797 patients suffering a first MI and 796 controls. A weighted composite of EID was calculated as the sum of all teeth, excluding third molars.

Endodontic inflammatory disease: A risk indicator for a first myocardial infarction.

Aim: To study the association between endodontic inflammatory disease and a first myocardial infarction (MI).

Methodology: The study comprised 805 patients with recent experience of a first MI, each gender, age and geographically matched with a control. Panoramic radiographs were available for 797 patients and 796 controls.

Calibration improves observer reliability in detecting periapical pathology on panoramic radiographs.

Objective: To determine whether calibration improves observer reliability when assessing DMFT-score, root-filled teeth and periapical lesions on panoramic radiographs.

Material And Methods: A sample of 100 panoramic radiographs was selected from a cohort of myocardial infarction patients ( = 797) and matched controls ( = 796). The following variables were assessed: DMFT-score, remaining teeth, root-filled teeth and periapical lesions.

Differentiation of periapical granuloma from radicular cyst using cone beam computed tomography images texture analysis.

Objective: This study aimed to investigate the use of texture analysis for characterization of radicular cysts and periapical granulomas and to assess its efficacy to differentiate between both lesions with histological diagnosis.

Methods: Cone beam computed tomography (CBCT) images were obtained from 19 patients with 25 periapical lesions (14 radicular cysts and 11 periapical granulomas) confirmed by biopsy. Regions of interest were created in the lesions from which 11 texture parameters were calculated.

Presence of langerhans cells, regulatory T cells (Treg) and mast cells in asymptomatic apical periodontitis.

Asymptomatic Apical Periodontitis is essentially an inflammatory disease of microbial aetiology. Association and function of the cell components involved, or specific inductive factors and growth mediators associated with development, maintenance and resolution of the periapical lesions are still unknown. The objective of this study was to evaluate the concentration of Regulatory T cells (FoxP3+; Treg), Langerhans cells (CD1a+; LC) and mast cells in asymptomatic apical periodontitis.

Comparing Quality of Life of Patients Undergoing Root Canal Treatment or Tooth Extraction.

Introduction: The knowledge of patient-centered outcomes concerning the consequences of root canal treatment in daily life is limited. The treatment option is often tooth extraction with possible prosthetic replacement. This study aimed to achieve a greater understanding of the patient perspective by evaluating the effect of root canal treatment in terms of quality of life and quality-adjusted life year (QALY) weights in comparison with patients who underwent tooth extraction.

Apical periodontitis as potential source of infection in patients with lymphoma treated with chemotherapy.

Objectives: To investigate signs of infection and infection-related complications of apical periodontitis (AP) in patients who underwent chemotherapy for lymphoma.

Materials And Methods: Data were collected retrospectively from the dental and medical records of patients receiving chemotherapy for lymphoma. Based on the findings from a dental evaluation made in conjunction with chemotherapy, the patients were divided into two groups, patients with or without teeth with AP.

Inflammatory profile of chronic apical periodontitis: a literature review.

Apical periodontitis caused by root canal infection is the most frequent pathological lesion in the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the formation and progression of apical periodontitis as well as the identification of inflammatory biomarkers can help increase the knowledge of pathogenic mechanisms, improve the diagnosis and provide support for different therapeutic strategies. The objective of the present article is to review inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers and to relate these systems to the development and progression of pathological conditions related to apical periodontitis.

Vital root resection with MTA: a pilot study.

Objectives: To investigate the outcome of vital root resection followed by immediate pulp capping with MTA in furcation involved maxillary molars.

Material And Methods: This pilot clinical study of 12 months duration was designed to evaluate the outcome of vital root resection in maxillary molars with degree II furcation involvement combined with conservative endodontic treatment by means of pulp capping with mineral trioxide aggregate (MTA). Seven teeth in six adult patients suffering from adult chronic periodontitis were included in this study.

Long-term survival of endodontically treated teeth at a public dental specialist clinic.

Introduction: The long-term survival of endodontically treated teeth is an issue of high priority focus in modern restorative dentistry. In available literature, survival is generally high and comparable with implants. For more compromised teeth treated in a specialist clinic, survival rate may be lower.