Use of recombinant activated factor VII in cardiac surgery for an effective treatment of severe intractable bleeding.

Experience gained with administration of supranormal-therapeutic doses (90 microg/kg) of recombinant activated factor VII in 7 cardiac surgery patients is presented. The patients were given recombinant activated factor VII postoperatively for intractable bleeding, 5 of them after surgical revision. Administration of recombinant activated factor VII was associated with significant reduction in blood loss (P < 0.

Less invasive cardiac anesthesia: an ultra-fast-track procedure avoiding thoracic epidural analgesia.

Background And Objective: A new "less invasive" technique avoiding thoracic epidural analgesia has be en tested for suitability as a routine procedure for cardiac anesthesia. Early postoperative extubation is an important step in this fasttrack procedure.

Materials And Methods: Consecutive patients (n = 547; age, 35-82 years; mean age, 64 year s; male to female ratio, 3.