Publications by authors named "Peter J m Weijs"

Background: Inadequate protein intake is associated with poor physical functioning and suboptimal recovery in hospitalised older adults. Despite standard dietetic care, dietary protein intakes falls well below the recommended levels. To address this problem, we developed an intensified trans-sectorial dietetic intervention that targets hospitalised older adults.

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Protein requirement in obesity.

Curr Opin Clin Nutr Metab Care

January 2025

Purpose Of Review: The combined obesity and ageing pandemic require action to avoid a total health system infarct. Obesity is largely challenged with caloric restriction and endurance exercise, likely to be assisted by drugs. The older adults with the highest obesity levels may face extreme loss of muscle mass and increased risk of sarcopenic obesity.

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Background: Our aim was to identify dietary patterns by the level of maternal education that contribute to BMI, fat mass index (FMI), and fat-free mass index (FFMI) in children at age 5 and to assess if these dietary patterns are related to BMI at age 10.

Methods: Per group (low/middle/high level), Reduced Rank Regression (RRR) was used to derive dietary patterns for the response variables BMI z-score, FMI, and FFMI in 1728 children at age 5 in the Amsterdam Born Children and their Development (ABCD) cohort. Regression analyses were then used to determine the association with BMI at age 10.

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Article Synopsis
  • The PRECISe trial aimed to determine if providing critically ill patients on mechanical ventilation with higher protein intake (2.0 g/kg per day) would enhance their quality of life and functional recovery compared to standard protein intake (1.3 g/kg per day).
  • This double-blinded, multicentre trial included patients from 10 hospitals across the Netherlands and Belgium, focusing on those expected to need invasive ventilation for at least three days.
  • Key aspects of the study included random assignment to either the standard or high-protein group, with blinding of all involved personnel, and tracking the primary outcome through health utility scores at specified intervals (30, 90, and 180 days post-randomization).
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Article Synopsis
  • Accurate diagnosis of sarcopenia involves assessing muscle quality, specifically how much fat is infiltrated in muscle tissue, which is crucial for predicting mortality in TAVI patients.
  • The study analyzed CT scans from 1199 patients who underwent TAVI between 2010 and 2020, employing deep learning algorithms to measure skeletal muscle density (SMD) and intermuscular adipose tissue (IMAT).
  • Results indicated that low muscle quality, identified through both low SMD and high IMAT, significantly correlates with increased mortality risk, suggesting that muscle quality metrics are valuable predictors of health outcomes post-TAVI.
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Background: Sarcopenic obesity significantly burdens health and autonomy. Strategies to intervene in or prevent sarcopenic obesity generally focus on losing body fat and building or maintaining muscle mass and function. For a lifestyle intervention, it is important to consider psychological aspects such as behavioral change techniques (BCTs) to elicit a long-lasting behavioral change.

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Background: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.

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Importance: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.

Objective: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.

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Objectives: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes.

Methods: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention.

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Combined nutrition and exercise interventions potentially improve protein-energy wasting/malnutrition-related outcomes in patients with chronic kidney disease (CKD). The aim was to systematically review the effect of combined interventions on nutritional status, muscle strength, physical performance and QoL. MEDLINE, Cochrane, Embase, Web of Science and Google Scholar were searched for studies up to the date of July 2023.

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This study evaluates the concurrent validity of five malnutrition screening tools to identify older hospitalized patients against the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria as limited evidence is available. The screening tools Short Nutritional Assessment Questionnaire (SNAQ), Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), Mini Nutritional Assessment-Short Form (MNA-SF), and the Patient-Generated Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs for both malnutrition (conservative) and moderate malnutrition or risk of malnutrition (liberal) were used. The concurrent validity was determined by the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the level of agreement by Cohen's kappa.

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Article Synopsis
  • ICU patients experience rapid muscle loss, and maintaining muscle mass may enhance survival and quality of life; increasing protein intake (recommended 1.2 to 2.0 g/kg) could help.* -
  • A systematic review and meta-analysis included 29 studies analyzing various outcomes related to protein intake among ICU patients, focusing on those receiving ≥1.2 g/kg versus <1.2 g/kg.* -
  • Results indicated that higher protein intake (over 1.2 g/kg) was linked to improved nitrogen balance, increased muscle mass, and potentially reduced 60-day mortality, but more research on long-term quality of life effects is needed.*
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Objective: This systematic review aims to reevaluate the role of minerals on muscle mass, muscle strength, physical performance, and the prevalence of sarcopenia in community-dwelling and institutionalized older adults.

Design: Systematic review.

Setting And Participants: In March 2022, a systematic search was performed in PubMed, Scopus, and Web of Sciences using predefined search terms.

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Background: Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating skeletal muscle breakdown. Supporting evidence is limited however and results in great variety in recommended protein targets.

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Objective: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).

Design: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management.

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Background: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.

Method: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO.

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Referral to home-based cardiac rehabilitation (HBCR) is low among older and frailer patients due to low expectations regarding adherence by healthcare professionals. The aim of this study was to determine adherence to HBCR when old and frail patients are referred, and to explore any differences in baseline characteristics between adherent and nonadherent patients. Data of the Cardiac Care Bridge were used (Dutch trial register NTR6316).

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Introduction: The association between obesity and outcome in critical illness is unclear. Since the amount of visceral adipose tissue(VAT) rather than BMI mediates the health effects of obesity we aimed to investigate the association between visceral obesity, BMI and 90-day mortality in critically ill patients.

Method: In 555 critically ill patients (68% male), the VAT Index(VATI) was measured using Computed Tomography scans on the level of vertebra L3.

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The retirement phase is an opportunity to integrate healthy (nutrition/exercise) habits into daily life. We conducted this systematic review to assess which nutrition and exercise interventions most effectively improve body composition (fat/muscle mass), body mass index (BMI), and waist circumference (WC) in persons with obesity/overweight near retirement age (ages 55-70 y). We conducted a systematic review and network meta-analysis (NMA) of randomized controlled trials, searching 4 databases from their inception up to July 12, 2022.

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Aims: This systematic review and meta-analysis evaluates the additional effect of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes.

Methods: Embase, Medline, Web of Science and Cochrane Central databases were evaluated, and 11 studies were included. Random-effects meta-analysis was performed on body weight and measures of body composition and glycaemic control, to compare the effect of hypocaloric diet plus exercise with hypocaloric diet alone.

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Article Synopsis
  • - The review examines the effectiveness of nutritional and exercise interventions in managing sarcopenic obesity in individuals aged 50 to 70 years, highlighting the potential of these strategies during retirement.
  • - A total of 11 randomized controlled trials were included after screening 261 studies, focusing on interventions lasting at least 8 weeks with community-dwelling participants.
  • - Meta-analysis revealed that resistance training significantly reduced body fat, increased muscle mass and strength, and slightly improved gait speed, while combined protein and exercise interventions also contributed to fat mass reduction.
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Background: Early Childhood Education and Care (ECEC) teachers at urban preschools are potential key figures to promote healthy behaviours in disadvantaged young children and to engage parents in lifestyle-related topics. An ECEC teacher-parent partnership regarding healthy behaviours may support parents and stimulate their children's development. However, it is not an easy task to establish such a collaboration and ECEC teachers need tools to communicate with parents about lifestyle-related topics.

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Objective: To determine the effect of a multidisciplinary lifestyle program in patients with RA with low-moderate disease activity.

Methods: In the 'Plants for Joints' (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.

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End-stage kidney disease patients treated with conventional hemodialysis (CHD) are known to have impaired physical performance and protein-energy wasting (PEW). Nocturnal hemodialysis (NHD) was shown to improve clinical outcomes, but the evidence is limited on physical performance and PEW. We investigate whether NHD improves physical performance and PEW.

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