Publications by authors named "Peter J O'Reilly"
Article Synopsis
- The study aims to assess the effectiveness of COVID-19 vaccines used in Nepal (inactivated, viral vector, mRNA) and investigate infections with variants of SARS-CoV-2 in a hospital setting.
- It involves a hospital-based case-control design where patients over 18 with COVID-19-like symptoms undergo antigen/PCR testing, collecting data on vaccine status and demographics to determine vaccine effectiveness.
- Ethical approvals were secured from relevant institutions, ensuring a thorough and responsible approach to understanding vaccine efficacy and variant circulation in Nepal, aiming to enhance public health strategies.
Background: In Nepal, Streptococcus pneumoniae (pneumococcus) is a common cause of bacterial pneumonia in children, and is a major health concern. There are few data on the effect of vaccination on the disease or colonisation with pneumococci in the nasopharynx of children in this setting. The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced into the routine infant immunisation schedule in Nepal in 2015.
View Article and Find Full Text PDFBackground: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa.
Introduction: Typhoid fever continues to have a substantial impact on human health, especially in Asia and sub-Saharan Africa. Access to safe water, and adequate sanitation and hygiene remain the cornerstone of prevention, but these are not widely available in many impoverished settings. The emergence of antibiotic resistance affects typhoid treatment and adds urgency to typhoid control efforts.
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