Publications by authors named "Peter J Nash"
The 2014 Ebola outbreak in West Africa, the largest outbreak on record, highlighted the need for novel approaches to therapeutics targeting Ebola virus (EBOV). Within the EBOV replication complex, the interaction between polymerase cofactor, viral protein 35 (VP35), and nucleoprotein (NP) is critical for viral RNA synthesis. We recently identified a peptide at the N-terminus of VP35 (termed NPBP) that is sufficient for interaction with NP and suppresses EBOV replication, suggesting that the NPBP binding pocket can serve as a potential drug target.
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- Influenza viruses pose a significant global health threat, with limited antiviral options due to the rise of drug-resistant strains, making hemagglutinin (HA) a crucial target for new treatments.
- Recent research has led to the discovery of two promising small molecules, MBX2329 and MBX2546, which effectively inhibit HA-mediated viral entry, showing low toxicity and strong selectivity against various influenza strains.
- Both compounds interact with the stem region of HA and have potential for further development as therapeutic options, while also serving as valuable tools for understanding the virus's entry mechanisms.
Article Synopsis
- The study aimed to identify how psoriatic arthritis (PsA) relates to different categories of the International Classification of Functioning, Disability and Health (ICF), focusing on its impacts on patients' daily lives.
- Data was collected from 94 PsA patients in rheumatology clinics, assessing how many had impairments in ICF categories like Body Functions, Body Structures, Participation, and Environmental Factors.
- The findings revealed significant impairments in multiple ICF categories among PsA patients and indicated that environmental factors were often helpful, but the correlation with self-reported measures wasn't as expected, highlighting a need for improved methods in measuring these impacts.