Publications by authors named "Peter J J M Weterings"
Article Synopsis
- The study examined the effects of perchlorate (ClO) and nitrate (NO) on the metamorphosis of Xenopus laevis larvae by exposing them to various concentrations over 32 days.
- Significant developmental delays and thyroid issues were noted at higher concentrations of perchlorate, with the no observed effect concentrations being 25.0 μg/L for development and 3125 μg/L for growth.
- In contrast, while nitrate exposure did not harm metamorphosis or growth, it showed a decreasing trend in developmental stage distribution at higher concentrations, indicating different impacts compared to perchlorate.
The present study evaluated the hypothesis that dietary quality used in historical studies may impact the effects of chemical stressors on premetamorphic development and metamorphosis due to suboptimal nutritional quality. A modified Amphibian Metamorphosis Assay (AMA) was performed in which Nieuwkoop and Faber (NF) Stage 47 tadpoles of Xenopus laevis were exposed for 32 days to iodide (I )-deficient FETAX solution supplemented with <0.025, 0.
View Article and Find Full Text PDFPotential adverse effects of chemical substances on thyroid function are usually examined by measuring serum levels of thyroid-related hormones. Instead, recent risk assessments for thyroid-active chemicals have focussed on iodine uptake inhibition, an upstream event that by itself is not necessarily adverse. Establishing the extent of uptake inhibition that can be considered de minimis, the chosen benchmark response (BMR), is therefore critical.
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