Optic nerve invasion of uveal melanoma.

The aim of the study was to identify the histopathological characteristics associated with the invasion of the optic nerve of uveal melanoma and to evaluate the association between invasion of the optic nerve and survival. In order to achieve this, all uveal melanomas with optic nerve invasion in Denmark between 1942 and 2001 were reviewed (n=157). Histopathological characteristics and depth of optic nerve invasion were recorded.

Optic nerve invasion of uveal melanoma: clinical characteristics and metastatic pattern.

Purpose: To determine the frequency of optic nerve invasion in uveal melanoma, to identify clinical factors associated with optic nerve invasion, and to analyze the metastatic pattern and the association with survival.

Methods: All iris, ciliary body, and choroidal melanomas (N = 2758) examined between 1942 and 2001 at the Eye Pathology Institute, University of Copenhagen, Denmark, and the Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark, were reviewed. Cases with optic nerve invasion were identified and subdivided into prelaminar or laminar invasion and postlaminar invasion.

Visual outcome, local tumour control, and eye preservation after 106Ru/Rh brachytherapy for choroidal melanoma.

To study the visual outcome, local tumour control, and eye preservation 5 years after ruthenium/rhodium 106 brachytherapy for choroidal melanoma. The study included 55 consecutive patients treated by 106Ru/Rh brachytherapy for a choroidal melanoma during the period 1988-2000 and followed through 2004. The 5-year probability for not losing at least 5 Snellen lines was 59% (n = 45), for retaining a visual acuity of 0.

Prognostic factors for survival after enucleation for choroidal and ciliary body melanomas.

Purpose: To evaluate prognostic factors for the survival of patients treated by enucleation for choroidal and ciliary body melanomas.

Methods: The study included 293 consecutive patients (147 men and 146 women) treated by enucleation for a choroidal or ciliary body melanoma during the period 1955-2000. The median age at treatment was 61 years (range 26-88 years).

Have choroidal and ciliary body melanomas changed during the period 1955-2000?

Purpose: To establish whether the presentation of choroidal and ciliary body melanomas and patient survival have changed during the period 1955-2000.

Method: The study included 209 unselected patients (97 men, 112 women) from Arhus County during the period 1955-2000. The median age at treatment was 64 years (range 26-88 years).