A remark on constrained von Kármán theories.

We derive the Euler-Lagrange equation corresponding to 'non-Euclidean' convex constrained von Kármán theories.

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

Kinetochores are megadalton-sized protein complexes that mediate chromosome-microtubule interactions in eukaryotes. How kinetochore assembly is triggered specifically on centromeric chromatin is poorly understood. Here we use biochemical reconstitution experiments alongside genetic and structural analysis to delineate the contributions of centromere-associated proteins to kinetochore assembly in yeast.

CENP-T proteins are conserved centromere receptors of the Ndc80 complex.

Centromeres direct the assembly of kinetochores, microtubule-attachment sites that allow chromosome segregation on the mitotic spindle. Fundamental differences in size and organization between evolutionarily distant eukaryotic centromeres have in many cases obscured general principles of their function. Here we demonstrate that centromere-binding proteins are highly conserved between budding yeast and humans.

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.

Kinetochores are large multiprotein complexes that connect centromeres to spindle microtubules in all eukaryotes. Among the biochemically distinct kinetochore complexes, the conserved four-protein Mtw1 complex is a central part of the kinetochore in all organisms. Here we present the biochemical reconstitution and characterization of the budding yeast Mtw1 complex.

Euler-Lagrange equations for variational problems on space curves.

We derive the Euler-Lagrange equations for a large class of variational problems on curves. Our result generalizes a recent result obtained in the literature. Moreover, it is simple and self-contained.

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.

Kinetochores must remain associated with microtubule ends, as they undergo rapid transitions between growth and shrinkage. The molecular basis for this essential activity that ensures correct chromosome segregation is unclear. In this study, we have used reconstitution of dynamic microtubules and total internal reflection fluorescence microscopy to define the functional relationship between two important budding yeast kinetochore complexes.

Antisaccade performance is related to genetic loading for schizophrenia.

Disturbances of the oculomotor system are promising endophenotypes for schizophrenia. Increased error rates in the antisaccade task and prolonged antisaccade latencies have been found in patients with schizophrenia and their first degree relatives. We investigated oculomotor performance in 41 parents of schizophrenia patients and 22 controls with a prosaccade task and an antisaccade task.

Timing of psychoeducational psychotherapeutic interventions in schizophrenic patients.

Psychoeducational interventions for schizophrenic outpatients and their key-persons have shown impressive long-term effects on the course of illness. Psychoeducation is suggested to be offered as early as possible to be most effective. This prospective randomized study examines the influence of pre-therapy duration of illness on the effects of a psychoeducative training.