Publications by authors named "Peter Holme Jensen"
Tetranectin is a homotrimeric protein containing a C-type lectin-like domain. This domain (TN3) can bind calcium, but in the absence of calcium, the domain binds a number of kringle-type protein ligands. Two of the calcium-coordinating residues are also critical for binding plasminogen kringle 4 (K4).
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- NCAM promotes axonal growth by interacting with FGFR, and also has a lesser-known ATPase activity.
- Researchers confirmed the direct interaction between NCAM and FGFR1 using surface plasmon resonance (SPR) and identified overlapping binding sites for FGFR and ATP through NMR analysis.
- ATP can inhibit the NCAM-FGFR interaction and, consequently, reduce neurite outgrowth, demonstrating a regulatory role in this process.