Successful treatment of paraneoplastic hypercalcemia in a patient with giant condyloma acuminatum: a case report.

Introduction: While paraneoplastic syndromes in patients with malignant and metastasizing tumors are common, they are rarely associated with skin tumors showing predominantly local growth patterns. This case report relates to a patient with giant condyloma acuminatum, also called Buschke-Löwenstein tumor, with paraneoplastic hypercalcemia, who was successfully treated with conservative treatment.

Case Presentation: The patient in question is a 48-year-old German man with a giant periscrotal tumor.

Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial.

Background: The presence of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients is associated with reduced clinical outcome. Bisphosphonate treatment was shown to eradicate DTC from BM in several studies. This controlled randomized open-label multi-center study aimed to investigate the influence of zoledronic acid (ZOL) on DTC and survival of breast cancer patients (Clinical Trial Registration Number: NCT00172068).

[Complete remission of multiple brain metastases of non-small cell lung cancer induced by gefitinib monotherapy].

Background: While the activity of tyrosine kinase inhibitors as the first line treatment for primary tumors in patients with stage IV non-small cell lung cancer and a positive EGF receptor mutation is well known, little data on the efficacy in controlling cerebral metastases are available.

Case Report And Results: A 43-year-old woman was diagnosed with non-small cell lung cancer with cerebral and hepatic metastases. Emergency radiation therapy was initiated at the time of diagnosis due to superior vena cava syndrome.

Painful spinal cord compression as a complication of extramedullary hematopoiesis associated with beta-thalassemia intermedia.

Background: Spinal cord compression due to extramedullary hematopoiesis (EMH) is a rare manifestation of thalassemia. General therapeutic recommendations do not exist.

Case Report: We report a 23 year old male with beta-thalassemia intermedia and back pain resistant to analgetic medication.

Molecular targeting of the lymphovascular system for imaging and therapy.

Progress toward targeting cancer cells is a multi-disciplinary endeavor. In addition to the surgical and oncology specialties, radiologists collaborate with mathematicians, computer scientists, and physicists, in a constant effort to incrementally improve upon the current imaging modalities. Recently, radiologists have formed collaborations with molecular biologists and chemists in order to develop molecular agents that target cancer cells via receptor-substrate or specific physiochemical interactions.