Publications by authors named "Peter Habib Gerges"
How multipotent progenitors give rise to multiple cell types in defined numbers is a central question in developmental biology. Epigenetic switches, acting at single gene loci, can generate extended delays in the activation of lineage-specifying genes and impact lineage decisions and cell type output. Here, we analyzed a timed epigenetic switch controlling expression of mouse Bcl11b, a transcription factor that drives T-cell commitment, but only after a multi-day delay.
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- The COVID-19 pandemic posed significant challenges for researchers and healthcare providers, with genetic factors like Single nucleotide variants (SNVs) in ACE2 and TMPRSS2 genes potentially influencing disease severity.
- The study examined gene variants in Emirati patients, finding that they lacked previously identified variants linked to COVID-19 severity, but identified a new variant associated with worse outcomes specifically in female patients.
- Results indicated that this new genetic variant affected gene transcription and was correlated with increased levels of certain cytokines and chemokines, highlighting the role of genetic factors in COVID-19 susceptibility and severity across different populations.
Affinity-matured plasma cells (PCs) of varying lifespans are generated through a germinal center (GC) response. The developmental dynamics and genomic programs of antigen-specific PC precursors remain to be elucidated. Here, using a model antigen in mice, we demonstrate biphasic generation of PC precursors, with those generating long-lived bone marrow PCs preferentially produced in the late phase of GC response.
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