Discrimination, religious affiliation, and arterial stiffness in African American women and men.

Objective: This study examined the interactive relations of experienced interpersonal discrimination, sex, and religious affiliation with pulse wave velocity (PWV), a noninvasive measure of arterial stiffness and indicator of subclinical cardiovascular disease (CVD) prognostic for clinical CVD.

Method: We used multivariable linear regression analyses with cross-sectional data from 797 African American midlife adults in the Healthy Aging in Neighborhoods of Diversity Across the Life Span study in Baltimore, Maryland, to examine the interactive relations of both linear and quadratic discrimination, religious affiliation status, and sex with PWV in models adjusted for age and poverty status.

Results: Findings revealed a significant three-way interaction of Discrimination² × Religious Affiliation Status × Sex with PWV ( = 0.

Interactive Relations of Body Mass Index, Cardiorespiratory Fitness, and Sex to Cognitive Function in Older Adults.

Objective: The course of cognitive aging is influenced by multiple health factors. This cross-sectional study investigated the interactive relations between body mass index (BMI), maximum oxygen consumption (VO2max), and sex on neuropsychological outcomes in community-dwelling predominantly older adults.

Methods: Participants were 164 healthy adults [M (SD) = 64.

Red Cell Distribution Width, Anemia, and Brain Volumetric Outcomes Among Middle-Aged Adults.

Background: Anemia and red cell distribution width (RDW) have been linked to poor cognitive performance, pending studies of underlying mechanisms.

Objective: We examined cross-sectional relationships of initial RDW status (v1), RDW change (δ), and anemia with brain structural magnetic resonance imaging (sMRI) markers, including global and cortical brain and hippocampal and white matter lesion (WML) volumes, 5-6 years later.

Methods: Data were used from three prospective visits within the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study with complete v1 (2004-2009) and v2 (2009-2013) exposures and ancillary sMRI data at vscan (2011-2015, n = 213, mean v1 to vscan time: 5.

Biochemical and Hematological Correlates of Elevated Homocysteine in National Surveys and a Longitudinal Study of Urban Adults.

Elevated blood homocysteine (Hcy) among middle-aged adults can increase age-related disease risk, possibly through other biochemical and hematological markers. We selected markers for hyperhomocysteinemia among middle-aged adults, studied time-dependent Hcy-marker associations and computed highly predictive indices of hyperhomocysteinemia, with cross-sectional and longitudinal validations. We used data from the National Health and Nutrition Examination Survey (NHANES III, phase 2, = 4000), the NHANES 1999-2006 ( = 10,151) and pooled NHANES (cross-sectional validation).