Approach to allergic rhinitis in the primary care setting.

Background: Allergic rhinitis (AR) is a common condition that affects 19% of Australians in the community, accounting for approximately 0.6% of all general practitioner presentations. Recent years have seen the emergence of new treatment options, many of which can be delivered in the primary care setting.

Survey of Australian general paediatricians regarding insulin initiation practices in children with new onset of type 1 diabetes.

Aim: Australian and New Zealand (NZ) paediatric endocrinologists' and NZ general paediatricians' insulin initiation strategies for children with type 1 diabetes (T1D) was recently described. The aim of this study was to document the insulin initiation practices of Australian general paediatricians in newly diagnosed children with T1D.

Methods: An online survey was sent to Australian general paediatricians identified through the Australian Paediatric Society diabetes database.

Glycemic Outcome Associated With Insulin Pump and Glucose Sensor Use in Children and Adolescents With Type 1 Diabetes. Data From the International Pediatric Registry SWEET.

Objective: Insulin delivery methods, glucose-monitoring modalities, and related outcomes were examined in a large, international, diverse cohort of children and adolescents with type 1 diabetes from the Better Control in Pediatric and Adolescent Diabetes: Working to Create Centers of Reference (SWEET) -Registry.

Research Design And Methods: Participants with type 1 diabetes of ≥1 year, aged ≤18 years, and who had documented pump or sensor usage during the period August 2017-July 2019 were stratified into four categories: injections-no sensor (referent); injections + sensor; pump-no sensor; and pump + sensor. HbA and proportion of patients with diabetic ketoacidosis (DKA) or severe hypoglycemia (SH) were analyzed; linear and logistic regression models adjusted for demographics, region, and gross domestic product per capita were applied.

Bubble formation occurs in insulin pumps in response to changes in ambient temperature and atmospheric pressure but not as a result of vibration.

Introduction: Bubble formation in insulin pump giving sets is a common problem. We studied change in temperature, change in atmospheric pressure, and vibration as potential mechanisms of bubble formation.

Methods: 5 Animas 2020 pumps with 2 mL cartridges and Inset II infusion systems, 5 Medtronic Paradigm pumps with 1.

Changes in altitude cause unintended insulin delivery from insulin pumps: mechanisms and implications.

Objective: Children and adults with type 1 diabetes who receive insulin pump therapy have reported hypoglycemia during air travel. We studied the effects of atmospheric pressure on insulin pump delivery.

Research Design And Methods: Ten insulin pumps were connected to capillary tubes.

A 'radical' new rural model for pediatric diabetes care.

Objective: The purpose of the study was to evaluate a new rural Australian multidisciplinary model of pediatric diabetes care.

Methods: In 2007, in response to insurmountable obstructions to establish an effective multidisciplinary team within the public health system, an Australian rural pediatric practice created a private multidisciplinary diabetes care model. The 'Rural Australian Diabetes -Inspiring Control Activity & Lifestyle' model -'RADICAL'-comprised a locally based, co-located core team of general pediatrician, diabetes educator, and mental health nurse.

Simple, robust strategies for generating DNA-directed RNA interference constructs.

We describe two complementary strategies for preparing DNA-directed RNA interference (ddRNAi) constructs designed to express hpRNA. The first, oligonucleotide assembly (OA), uses a very simple annealing protocol to combine up to 20 short nucleotides. These are then cloned into appropriately designed restriction sites in expression vectors.