Different PSMA Radiopharmaceuticals: A Comparative Study of [F]F-PSMA-1007, [F]F-JK-PSMA-7, and [Tc]Tc-PSMA-I&S in the Skeletal System.

Background: Numerous PSMA-based tracers are used for diagnostic prostate cancer imaging, but comprehensive comparisons between multiple ligands are lacking. This study aimed to compare physiological skeletal uptake and tracer uptake in commonly recommended PSMA reference regions across three different PSMA ligands in prostate cancer patients.

Methods: A total of 281 prostate cancer patients were included.