Publications by authors named "Peter Flores"

Article Synopsis
  • SARS-CoV-2 is a highly contagious virus responsible for COVID-19, which has infected around 260 million people since late 2019, with severity linked to viral and host inflammatory responses that can lead to organ failure.
  • The study investigates the controversial effects of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) on mortality in severe COVID-19 cases, particularly their interaction with the bradykinin pathway.
  • Conducted as a multicenter retrospective study, it analyzed data from 2,935 COVID-19 patients treated in six Southern California hospitals to assess the impact of pre-hospital ACEi and ARB usage on in-hospital mortality rates.*
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Pacific Islanders experience high rates of cervical cancer incidence and mortality. This cross-sectional study examined the extent to which Samoan, Chamorro, and Tongan women's perceived receipt of social support from their husbands or male partners was associated with rates of routine cancer screening- specifically Pap testing. A total of 585 Pacific Islander women who live in the United States completed a self-report survey.

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Background: Pacific Islanders (PIs) experience high cervical cancer rates in the United States. Stage of diagnosis is also later for PIs than non-Hispanic Whites. The Pap test is severely underutilized among PIs: only 71% of Asian American and Pacific Islander women age 25 years or older received a Pap test within the last 3 years (U.

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Purpose: Trastuzumab resistance has been linked to activation of the phosphoinositol 3-kinase (PI3K) pathway. Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3K function; PTEN loss leads to activation of the Akt cascade and the downstream mammalian target of rapamycin (mTOR). Preclinical studies demonstrated that mTOR inhibition sensitized the response to trastuzumab in mice with HER2 overexpressing and PTEN-deficient breast xenografts.

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