Changes in Expression of Key Genes in Ceca of Chicken Broilers as Affected by Glyphosate, Antibiotics and a Coccidiostat.

Studies have shown the presence of residual amounts of the herbicide glyphosate in poultry feed, which leads to its bioaccumulation in the body. Recently, it has been established that exposure to low levels of glyphosate over a long period may have serious negative effects on poultry health. Moreover, combined exposure to several toxicants can potentially lead to additive and/or synergistic effects.

Nutrigenomics of Natural Antioxidants in Broilers.

The broiler industry supplies high-quality animal protein to the world. The ban of antibiotics as growth promoters has opened the way for plenty of phytochemicals and antioxidants to be explored. This study summarizes the use of natural antioxidants in a broiler diet as a way through which to deal with stressors, as well as their effects on the expression of various genes.

Silymarin and Inflammation: Food for Thoughts.

Inflammation is a vital defense mechanism, creating hostile conditions for pathogens, preventing the spread of tissue infection and repairing damaged tissues in humans and animals. However, when inflammation resolution is delayed or compromised as a result of its misregulation, the process proceeds from the acute phase to chronic inflammation, leading to the development of various chronic illnesses. It is proven that redox balance disturbances and oxidative stress are among major factors inducing NF-κB and leading to over-inflammation.

Probiotics as an alternative to antibiotics in modulating the intestinal microbiota and performance of broiler chickens.

Aims: Gut bacteria play an important role in poultry nutrition and the immune defense system. Changes in the intestinal microbiome affect the physiological state, metabolism, and innate immunity of poultry. The present study aimed to characterize age-related changes in the gastrointestinal tract microflora in broiler chickens, depending on supplementation of the diet with the in-feed antibiotic Stafac® 110 and a Bacillus subtilis strain-based probiotic.

The Effect of Dietary Inclusion of Microalgae spp. on Ewes' Milk Quality and Oxidative Status.

An unprecedented challenge for nutritionists arises during the 21st century in order to produce highly nutritious and functional food which promotes human health. Polyunsaturated fatty acids (PUFA) that are highly contained in microalgae have broadly been confirmed for preventing cardiovascular diseases and regulating immune-oxidative status. However, their optimum dietary inclusion level needs to be defined since PUFA are prone to oxidation.

Antioxidant Defences and Redox Homeostasis in Animals.

For many years reactive oxygen species (ROS) production in biological systems has been considered to be detrimental [...

Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models.

Natural antioxidants have received tremendous attention over the last 3 decades. At the same time, the attitude to free radicals is slowly changing, and their signalling role in adaptation to stress has recently received a lot of attention. Among many different antioxidants in the body, taurine (Tau), a sulphur-containing non-proteinogenic β-amino acid, is shown to have a special place as an important natural modulator of the antioxidant defence networks.

Effects of Essential Oils-Based Supplement and Infection on Gene Expression, Blood Parameters, Cecal Microbiome, and Egg Production in Laying Hens.

One of the main roles in poultry resistance to infections caused by is attributed to host immunity and intestinal microbiota. We conducted an experiment that involved challenging Lohmann White laying hens with Enteritidis (SE), feeding them a diet supplemented with an EOs-based phytobiotic Intebio. At 1 and 7 days post-inoculation, the expression profiles of eight genes related to immunity, transport of nutrients in the intestine, and metabolism were examined.

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB.

Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks.

Food for thought: nano-selenium in poultry nutrition and health.

In recent years, nanoparticles have become a fashionable subject of research due to their sizes, shapes, and unique intrinsic physicochemical properties. In particular for the last 5 years, nano-Se has received tremendous attention in terms of its production, characteristic, and possible application for poultry/animal science and medical sciences. Indeed, Nano-Se is shown to be a potential source of Se for poultry/animal nutrition.

Antioxidants in Poultry Nutrition and Reproduction: An Update.

For the last three decades poultry [...

Examination of the Expression of Immunity Genes and Bacterial Profiles in the Caecum of Growing Chickens Infected with Enteritidis and Fed a Phytobiotic.

This study was performed to investigate the differential expression of eight immunity genes and the bacterial profiles in the caecum of growing chickens challenged with serovar Enteritidis (SE) at 1 and 23 days post inoculation (dpi) in response to SE infection at 19 days of age and administration of the phytobiotic Intebio. Following infection, the genes and were upregulated by greater than twofold. Chicks fed Intebio showed at 1 dpi upregulation of , , , and .

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update.

Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poultry production. During evolution, antioxidant defence systems were developed in poultry to survive in an oxygenated atmosphere.

Revisiting Oxidative Stress and the Use of Organic Selenium in Dairy Cow Nutrition.

In commercial animals production, productive stress can negatively impact health status and subsequent productive and reproductive performance. A great body of evidence has demonstrated that as a consequence of productive stress, an overproduction of free radicals, disturbance of redox balance/signaling, and oxidative stress were observed. There is a range of antioxidants that can be supplied with animal feed to help build and maintain the antioxidant defense system of the body responsible for prevention of the damaging effects of free radicals and the toxic products of their metabolism.

Nutritional modulation of the antioxidant capacities in poultry: the case of vitamin E.

Commercial poultry production is associated with a range of stresses, including environmental, technological, nutritional, and internal/biological ones, responsible for decreased productive and reproductive performance of poultry. At the molecular level, most of them are associated with oxidative stress and damages to important biological molecules. Poultry feed contains a range of feed-derived and supplemented antioxidants and, among them, vitamin E is considered as the "headquarters" of the antioxidant defense network.

Nutritional modulation of the antioxidant capacities in poultry: the case of selenium.

Natural antioxidants play important roles in maintaining chicken health, productive and reproductive performance of breeders, layers, rearing birds, and growing broilers. There is a wide range of antioxidant molecules in the body: vitamin E, carotenoids, selenium, ascorbic acid, coenzyme Q, carnitine, taurine, antioxidant enzymes, etc. In the body all antioxidants work together to create the antioxidant network called "antioxidant systems" with Se being the "chief-executive.

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources.

Selenium (Se) is an essential element in poultry nutrition and its bio-efficacy depends on its chemical form. A growing body of research proves that organic forms of Se, mainly selenomethionine (SeMet), in poultry diets have a range of important advantages over traditional sodium selenite. In fact, the organic Se concept considers SeMet as a storage form of Se in the chicken body.

Nano-Se Assimilation and Action in Poultry and Other Monogastric Animals: Is Gut Microbiota an Answer?

Recently, a comprehensive review paper devoted to roles of nano-Se in livestock and fish nutrition has been published in the Nanoscale Research Letters. The authors described in great details an issue related to nano-Se production and its possible applications in animal industry and medicine. However, molecular mechanisms of nano-Se action were not described and the question of how nano-Se is converted into active selenoproteins is not resolved.

Antioxidant systems in chick embryo development. Part 1. Vitamin E, carotenoids and selenium.

Chick viability is known to be an important factor determining profitability of the poultry industry. Chick embryo tissues contain a high proportion of highly polyunsaturated fatty acids in the lipid fraction and therefore need antioxidant defence. The antioxidant system of the developing embryo and newly hatched chick includes the antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase), water-soluble antioxidants (ascorbic acid, taurine, carnitine, glutathione, etc.

Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives.

Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various flavonolignans (with silybin being the major one), has received a tremendous amount of attention over the last decade as a herbal remedy for liver treatment. In many cases, the antioxidant properties of SM are considered to be responsible for its protective actions. Possible antioxidant mechanisms of SM are evaluated in this review.

Selenium in pig nutrition and reproduction: boars and semen quality-a review.

Selenium plays an important role in boar nutrition via participating in selenoprotein synthesis. It seems likely that selenoproteins are central for antioxidant system regulation in the body. Se-dependent enzyme glutathione peroxidase (GSH-Px) is the most studied selenoprotein in swine production.

Changes in broiler chick tissue concentrations of lipid-soluble antioxidants immediately post-hatch.

The antioxidant protection of the chicken (Gallus gallus) embryo during incubation and early postnatal development plays an important role in chick viability. To assess the antioxidant capacity of the newly hatched chick, we determined the concentrations of vitamin A, vitamin E, carotenoids and coenzyme Q₁₀ in the major tissues of chicks which had been held in an incubator for up to 36 h post-hatch. Concentrations of total carotenoids and free retinol and retinol esters in the tissues did not differ significantly over the 36 h period post-hatch (p>0.