Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding.

Aim: To determine the frequency of small bowel ulcerative lesions in patients with peptic ulcer and define the significance of those lesions.

Methods: In our prospective study, 60 consecutive elderly patients with upper gastrointestinal bleeding from a peptic ulceration (cases) and 60 matched patients with a non-bleeding peptic ulcer (controls) underwent small bowel capsule endoscopy, after a negative colonoscopy (compulsory in our institution). Controls were evaluated for non-bleeding indications.

Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett's esophagus.

The incidence of esophageal adenocarcinoma, a poor prognosis neoplasia, has risen dramatically in recent decades. Barrett's esophagus represents the best-known risk factor for esophageal adenocarcinoma development. Non-steroidal anti-inflammatory drugs through cyclooxygenase-2 inhibition and prostaglandin metabolism regulation could control cell proliferation, increase cell apoptosis and regulate the expression of growth and angiogenic factors.