Publications by authors named "Peter David Austin"
Objectives: Because bloodstream infection and venous catheter (or cannula) bloodstream infection are associated with high morbidity and cost, early identification and treatment are important. Isothermal microcalorimetry can detect microbial growth using thermal power (heat flow), essentially in real time. The aim of this study was to examine the potential of this technique in clinical practice.
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- - This study investigates the effectiveness of seven 'prophylactic' locks in preventing infections in long-term intravenous catheters by measuring biofilm formation and viability of two bacteria: E. coli and S. epidermidis.
- - Various agents showed different levels of success; citrate was less effective against E. coli but better for S. epidermidis, while taurolidine was the strongest against E. coli but less so for S. epidermidis.
- - The research indicates that the effectiveness of these agents varies by bacterial species, suggesting that selecting the appropriate 'prophylactic' lock should consider the most likely infecting organism.
Objective: Catheter/cannula-bloodstream infection (CBI) has been proposed as a marker of the quality of care provided to patients receiving parenteral nutrition (PN). However, surveillance criteria for CBI are variable, inconsistent, and sometimes confusing and impractical. Surveillance criteria were developed to simply and accurately demonstrate the presence or absence of CBI.
View Article and Find Full Text PDFBackground: Recommendations effectively restrict the infusion duration of lipid-containing parenteral nutrition (PN) from a single bag, purportedly because it encourages growth of potential microbial contaminants more than lipid-free PN. Since other variables, including osmolarity, may independently affect microbial growth, this study examined variables affecting growth of Escherichia coli and Enterococcus durans in PN infusates.
Materials And Methods: Growth of E coli and E durans was assessed in quadruplicate in 12 different PN infusates, with and without lipid, in varying glucose concentrations.
Background: Handwritten recycled paper prescription for parenteral nutrition (PN) may become a concentrated source of viable contaminants, including pathogens. This study examined the effect of using fresh printouts of electronic prescriptions on these contaminants.
Materials And Methods: Cellulose sponge stick swabs with neutralizing buffer were used to sample the surfaces of PN prescriptions (n = 32 handwritten recycled; n = 32 printed electronic) on arrival to the pharmacy or following printing and PN prescriptions and bags packaged together during delivery (n = 38 handwritten recycled; n = 34 printed electronic) on arrival to hospital wards.
Purpose: To review microbial contamination rates about preparation of individual and batch doses using aseptic techniques within pharmaceutical (controlled) and clinical (ward and theatre) environments.
Methods: Systematic review, involving amalgamation of data using a random effect model and metaanalysis.
Results: A total of 19 studies from 17 reports (7277 doses), mostly single arm studies, were identified for analysis.