Publications by authors named "Peter Dau"
Article Synopsis
- Apoptosis is a controlled cellular death process crucial for maintaining tissue health and is linked to various diseases like cancer and neurodegenerative disorders.
- A new biosensor has been developed that combines Annexin V’s ability to target apoptotic cells with a sensitive bioluminescent signal from a modified Renilla luciferase, called ArFP, to effectively detect apoptosis.
- This innovative biosensor has been validated both in vitro and in vivo, showing promise for various clinical applications, such as cancer treatment monitoring and cardiovascular disease detection.
We have developed sensing systems employing different classes of transcriptional regulatory proteins genetically and chemically modified to incorporate a fluorescent reporter molecule for detection of arsenic, hydroxylated polychlorinated biphenyls (OH-PCBs), and cyclic AMP (cAMP). These are the first examples of optical sensing systems based on transcriptional regulatory proteins.
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