Using continuous glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30: a double-blind crossover study in individuals with type 2 diabetes.

Objective: Rapid-acting insulin analogs in basal-bolus regimens can reduce nocturnal hypoglycemia, so it is conceivable that twice-daily biphasic insulin analogs might reduce hypoglycemia in patients with insulin-treated type 2 diabetes. We used a continuous glucose monitoring system (CGMS) and self-reported episodes to investigate differences in the frequency of low glucose values in patients with type 2 diabetes, using either biphasic insulin aspart 30 (BIAsp 30) or biphasic human insulin 30 (BHI 30).

Research Design And Methods: This was a double-blind, two-period, crossover trial involving 160 subjects.

Load-deflection characteristics of superelastic nickel-titanium orthodontic wires.

Previous mechanical testing of orthodontic wires has, in many cases, failed to simulate some key features of the clinical environment. The purpose of this study was to investigate the load-deflection characteristics of 7 different 0.016-in initial alignment archwires (Twistflex, NiTi, and 5 brands of heat-activated superelastic nickel-titanium [HASN]) with modified bending tests simulating a number of conditions encountered clinically.