Fragment Hotspot Mapping to Identify Selectivity-Determining Regions between Related Proteins.

Selectivity is a crucial property in small molecule development. Binding site comparisons within a protein family are a key piece of information when aiming to modulate the selectivity profile of a compound. Binding site differences can be exploited to confer selectivity for a specific target, while shared areas can provide insights into polypharmacology.

Low temperature CVD of thermoelectric SnTe thin films from the single source precursor, [BuSn(TeBu)].

This work has demonstrated that the single source precursor [nBu3Sn(TenBu)], bearing n-butyl groups and containing the necessary 1 : 1 Sn : Te ratio, facilitates growth of continuous, stoichiometric SnTe thin films. This single source CVD precursor allows film growth at significantly lower temperatures (355-434 °C at 0.01-0.

Global Corner Spotlight: Perspectives on Diabetes Care in Cambodia as Seen Through an Ngo-Run Healthcare System.

CMC = Community Medical Center; SGLT2 = sodium-glucose cotransporter 2; SHCH = Sihanouk Hospital Center of Hope.

Leadership for Addressing Aging in America: The Health and Aging Policy Fellowship.

The Health and Aging Policy Fellows Program funded by The John A. Hartford Foundation and Atlantic Philanthropies trains future leaders to influence healthcare policy, systems, and program development in aging. Following a rigorous residential training in Washington, DC, Fellows establish placements of up to 1 year in the executive, legislative, or judicial branch of government, at a federal agency, state or community agency or committee, or with a nongovernmental organization.

Reconfigurable superconducting vortex pinning potential for magnetic disks in hybrid structures.

High resolution scanning Hall probe microscopy has been used to directly visualise the superconducting vortex behavior in hybrid structures consisting of a square array of micrometer-sized Py ferromagnetic disks covered by a superconducting Nb thin film. At remanence the disks exist in almost fully flux-closed magnetic vortex states, but the observed cloverleaf-like stray fields indicate the presence of weak in-plane anisotropy. Micromagnetic simulations suggest that the most likely origin is an unintentional shape anisotropy.

Efficient and facile synthesis of acrylamide libraries for protein-guided tethering.

A kinetic template-guided tethering (KTGT) strategy has been developed for the site-directed discovery of fragments that bind to defined protein surfaces, where acrylamide-modified fragments can be irreversibly captured in a protein-templated conjugate addition reaction. Herein, an efficient and facile method is reported for the preparation of acrylamide libraries from a diverse range of amine fragments using a solid-supported quaternary amine base.

Usefulness and safety of percutaneous coronary interventions for cardiac transplant vasculopathy.

Late morbidity and death as a result of progressive coronary vascular obliteration remains a major unsolved problem after orthotopic heart transplantation. Various percutaneous catheter intervention (PCI) methods have been used to treat transplant coronary artery disease (CAD), but few reports have assessed the longitudinal results of these procedures. Of 1,440 cardiac transplant patients at University of California, Los Angeles, Medical Center, treated between 1984 and 2004, 65 patients who had undergone orthotopic heart transplantation underwent PCI on a total of 156 coronary artery lesions because of transplant CAD between July 1993 and August 2004.

Coronary steal syndrome with coil embolization of a large LIMA side branch: radionuclide evidence for reversible ischemia.

This case presents the controversy over coronary artery steal syndrome following bypass surgery when a large branch of the left internal mammary artery (LIMA) is not ligated. A discussion of previous attempts to understand the physiology of this anatomy is compared with case reports of objective evidence for ischemia that resolves following occlusion of the LIMA side branch.

A tariff system for nervous shock: introducing the total impact score.

Objectives: This study was designed to test a proposed relationship between the total impact score (devised by the authors) and the quantum of damages in compensation received by victims of criminal and political violence. In so doing, the authors sought to develop a mathematical formula which could be used to quantify damages in a simple and expeditious manner.

Method: Data on 2,191 victims of violence was collated forming three databases of information, on the incident, on the victim and on the outcomes.

Percutaneous snare retrieval of a partially embedded Wallstent.

Although removal of a stent is a well described method for treating an acutely dislodged or embolized device, removal of a previously deployed stent is unusual. We describe a case where a partially dislodged wallstent in a saphenous vein graft was removed using a snare to permit deployment of a balloon mounted stent across a proximal vein graft stenosis.