Optimization of tablets containing a high dose of spray-dried plant extract: a technical note.

Optimization of CSD and CMC-Na in tablet formulations containing a high dose of SDE from was performed by central composite design (CCD) and response surface methodology (RSM). The study demonstrated that CSD affected mainly the hardness and friability, while CMC-Na modified the disintegration times. The optimum formula for minimum disintegration time and friability, and maximum crushing strength, was found to contain 1.

Dry granulation and compression of spray-dried plant extracts.

The purpose of this research was to evaluate the influence of dry granulation parameters on granule and tablet properties of spray-dried extract (SDE) from Maytenus ilicifolia, which is widely used in Brazil in the treatment of gastric disorders. The compressional behavior of the SDE and granules of the SDE was characterized by Heckel plots. The tablet properties of powders, granules, and formulations containing a high extract dose were compared.

Hydrophilic solutes in modified carbon dioxide extraction-prediction of the extractability using molecular dynamic simulation.

Super- and subcritical carbon dioxide (CO2) extractions of crude drugs were simulated by molecular modelling to predict the extractability of different hydrophilic plant constituents under various extraction conditions. The CO2 extraction fluids were simulated either with pure CO2 or with solvent modified CO2 at different pressures and temperatures. Molecular modelling resulted in three different solubility parameters: the total solubility parameter delta and the partial solubility parameters delta(d) for the van der Waals and delta(EL) for the polar forces.

Mechanism of glidants: investigation of the effect of different colloidal silicon dioxide types on powder flow by atomic force and scanning electron microscopy.

The effect of hydrophilic and hydrophobic colloidal silicon dioxide types (CSD) on the flow characteristics of microcrystalline cellulose (MCC) under different mixing conditions was macroscopically measured using the angle of repose method, the bulk and tapped densities. CSD ameliorated the flow characteristics in general, but hydrophobic CSD was more effective compared to the hydrophilic types under gentle mixing conditions. The macroscopic effect was explained on the particle level by scanning electron (SEM) and atomic force microscopy (AFM) studies.

Fast dispersible ibuprofen tablets.

Fast dispersible tablets disintegrate either rapidly in water, to form a stabilized suspension, or disperse instantaneously in the mouth to be swallowed without the aid of water. A direct compression method was used to prepare these two types of tablets containing coated ibuprofen as a high dosed model drug. The properties of the water dispersible tablet, such as porosity, hardness, disintegration time and increase in viscosity after dispersion, were investigated.