Malaria pervasiveness in Sub-Saharan Africa: Overcoming the scuffle.

Malaria has posed a momentous health and economic burden to the Sub-Saharan African region. The Sub-Saharan African region accounts for more than 90% of global malaria-related mortality and morbidity. Pregnant women and children under 5 years old are the most vulnerable.

L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats.

The modulating effects of seed oil (CPSO) on dyslipidemia and neuronal dysfunction in tramadol toxicity were studied. Fifty-six albino rats were divided into seven groups of eight rats each after a 2-week acclimatization period. All animals had unrestricted access to water and feed, and treatments were administered orally once daily for 42 days.

Protective effect of lyophilized extract against carboplatin-induced liver injury via inhibition of oxidative stress and inflammation in rats.

Patients who are receiving carboplatin therapy for cancer often experience toxic side effects. This study examined the effects of lyophilized aqueous leaf extracts of F. capensis (LALEFC) on oxidative stress and inflammatory markers in albino rats with carboplatin-damaged livers.

In silico pharmacokinetic and therapeutic evaluation of peels against aluminium chloride-induced hepatotoxicity in adult BALB/c mice.

East Africa ( spp.), notably , "Matooke" a staple and economically important food in the region. Here, 12 selected .

Piquing artificial intelligence towards drug discovery: Tools, techniques, and applications.

The purpose of this study was to discuss how artificial intelligence (AI) methods have affected the field of drug development. It looks at how AI models and data resources are reshaping the drug development process by offering more affordable and expedient options to conventional approaches. The paper opens with an overview of well-known information sources for drug development.

seed oil protects against Bisphenol A-induced testicular mitochondrial damages.

There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine-disrupting chemical capable of causing male infertility. This study aimed to explore seed oil effects against mitochondrial damage in rats using bisphenol A.

In-vivo and in-silico studies revealed the molecular mechanisms of phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α-reductase and α1-adrenoceptor.

Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the molecular mechanism of CE as a novel agent for BPH chemotherapy. In vivo we assigned 45 male Wistar albino rats about 6 weeks old into 9 experimental groups (n = 5).

Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay.

Background: Mondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves (MWL) lack chemical characterization of their bioactive components and possible molecular targets.