Predicting Gout Flares in People Starting Allopurinol Using the Start-Low Go-Slow Dose Escalation Strategy.

Objective: The study objective was to determine predictors of gout flare when commencing allopurinol using the "start-low go-slow" dose escalation strategy.

Methods: A post hoc analysis of a 12-month double-blind placebo-controlled noninferiority trial with participants randomized 1:1 to colchicine 0.5 mg daily or placebo for the first six months was undertaken.

Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial.

Objectives: To determine whether placebo is non-inferior to low-dose colchicine for reducing gout flares during the first 6 months of allopurinol using the 'start-low go-slow' dose approach.

Methods: A 12-month double-blind, placebo-controlled non-inferiority trial was undertaken. Adults with at least one gout flare in the preceding 6 months, fulfilling the American College of Rheumatology (ACR) recommendations for starting urate-lowering therapy and serum urate ≥0.

Giant cell arteritis: A population-based retrospective cohort study exploring incidence and clinical presentation in Canterbury, Aotearoa New Zealand.

Background/aim: To determine the epidemiology and clinical features of giant cell arteritis (GCA) in Canterbury, Aotearoa New Zealand, with a particular focus on extra-cranial large vessel disease.

Methods: Patients with GCA were identified from radiology and pathology reports, outpatient letters and inpatient hospital admissions in the Canterbury New Zealand from 1 June 2011 to 31 May 2016. Data was collected retrospectively based on review of electronic medical records.

The Prevalence, Magnitude, and Reversibility of Elevated Liver Enzyme Activities in Hyperthyroid Cats Presenting for Iodine-131 Treatment.

Objectives: The primary objective of this study was to report the prevalence and magnitude of elevated liver enzyme activity in feline hyperthyroidism using a large cohort of cats presenting for iodine-131 treatment. The secondary objective was to determine if elevated liver enzyme activity was a reversible process following successful iodine-131 treatment.

Methods: Cases that presented for a single iodine-131 treatment were retrospectively reviewed.

"There Is No (Where a) Like Home": Recognition and Appraisal Responses to Masked Facial of Emotion in Four Different National Cultures.

The theory of universal emotions suggests that certain emotions such as fear, anger, disgust, sadness, surprise and happiness can be encountered cross-culturally. These emotions are expressed using specific facial movements that enable human communication. More recently, theoretical and empirical models have been used to propose that universal emotions could be expressed via discretely different facial movements in different cultures due to the non-convergent social evolution that takes place in different geographical areas.

Adjusted calcium concentration as a predictor of ionized hypocalcemia in hypoalbuminemic dogs.

Background: Ionized calcium (iCa) is the biologically active fraction of total calcium (tCa) with clinical relevance to evaluate calcium homeostasis, but not all primary veterinarians have access to serum iCa. Formulas that adjust tCa to correct for variability in serum protein concentrations were not designed to predict iCa and are considered unreliable surrogates for iCa.

Objectives: To determine whether adjusted calcium concentration (aCa) can predict ionized hypocalcemia in hypoalbuminemic dogs without hyperphosphatemia.

Synthesis, characterisation and thermo-physical properties of highly stable graphene oxide-based aqueous nanofluids for potential low-temperature direct absorption solar applications.

Two types of highly stable 0.1% graphene oxide-based aqueous nanofluids were synthesised and investigated. The first nanofluid (GO) was prepared under the influence of ultrasonic irradiation without surfactant.

Individual conscious and unconscious perception of emotion: Theory, methodology and applications.

In this manuscript we review a seminal debate related to subliminality and concerning the relationship of consciousness, unconsciousness, and perception. We present the methodological implementations that contemporary psychology introduced to explore this relationship, such as the application of unbiased self-report metrics and Bayesian analyses for assessing detection and discrimination. We present evidence concerning an unaddressed issue, namely, that different participants and stimulus types require different thresholds for subliminal presentation.

The effect of a secondary task on drivers' gap acceptance and situational awareness at junctions.

The current studies explored the roles of the visuospatial and phonological working memory subsystems on drivers' gap acceptance and memory for approaching vehicles at junctions. Drivers' behaviour was measured in a high-fidelity driving simulator when at a junction, with, and without a visuospatial or phonological load. When asked to judge when to advance across the junction, gap acceptance thresholds, memory for vehicles and eye movements were not different when there was a secondary task compared to control.

Evaluating the impact of Heavy Goods Vehicle driver monitoring and coaching to reduce risky behaviour.

Determining the impact of driver-monitoring technologies to improve risky driving behaviours allows stakeholders to understand which aspects of onboard sensors and feedback need enhancement to promote road safety and education. This study investigates the influence of camera monitoring on Heavy Goods Vehicle (HGV) drivers' risky behaviours. We also assess whether monitoring affects individual driving events further when coupled with safe driving practices coaching.

"The Harder One Tries …": Findings and Insights From the Application of Covert Response Pressure Assessment Technology in Three Studies of Visual Perception.

In this article, we present a force measuring method for assessing participant responses in studies of visual perception. We present a device disguised as a mouse pad and designed to measure mouse-click-pressure and click-press-to-release-time responses by unaware, as regards to the physiological assessment, participants. The aim of the current technology, in the current studies, was to provide a physiological assessment of confidence and task difficulty.

Allopurinol hypersensitivity: Pathogenesis and prevention.

Allopurinol, a first line urate-lowering therapy, has been associated with serious cutaneous reactions that have a high mortality. A number of risk factors for these serious adverse reactions have been identified including ethnicity, HLA-B∗5801 genotype, kidney impairment, allopurinol starting dose, and concomitant diuretic use. There is a complex interplay between these risk factors, which may (albeit rarely) lead to allopurinol-related serious adverse events.

Lack of effect of tart cherry concentrate dose on serum urate in people with gout.

Objectives: Cherry concentrate has been suggested to reduce serum urate (SU) and gout flares. The aims of this study were to determine the magnitude of the effect of tart cherry concentrate on SU in people with gout, the most effective dose of tart cherry concentrate for lowering SU, and adverse effects.

Methods: Fifty people with gout and SU > 0.

The 'Saw but Forgot' error: A role for short-term memory failures in understanding junction crashes?

Motorcyclists are involved in an exceptionally high number of crashes for the distance they travel, with one of the most common incidents being where another road user pulls out into the path of an oncoming motorcycle frequently resulting in a fatal collision. These instances have previously been interpreted as failures of visual attention, sometimes termed 'Look but Fail to See' (LBFTS) crashes, and interventions have focused on improving drivers' visual scanning and motorcycles' visibility. Here we show from a series of three experiments in a high-fidelity driving simulator, that when drivers' visual attention towards and memory for approaching vehicles is experimentally tested, drivers fail to report approaching motorcycles on between 13% and 18% of occasions.

Anger and hostility: are they different? An analytical exploration of facial-expressive differences, and physiological and facial-emotional responses.

Previous research has proposed the exploratory hypotheses that hostility could differ from anger in the sense that it involves higher possibility for inflicting physical harm while anger could involve higher frustration and stress compared to hostility. Based on these hypotheses we tested whether there are expressive differences and discrete emotional responses between angry and hostile faces. We used participant assessment to preselect faces.

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.

Objective: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.

Methods: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them.

The challenges of managing gout in primary care: Results of a best-practice audit.

Background And Objectives: The aim of this project was to determine the effects of a package of care for gout in primary care.

Method: An audit of gout management in a single rural medical practice was undertaken before (in 2012) and after (in 2015) the introduction of the package of care reflecting guidelines in gout management.

Results: There was a statistically significant increase in the number of individuals commenced on allopurinol ≤100 mg/d and a decrease in the number commenced on allopurinol ≥200 mg/d (P <0.

How does drivers' visual search change as a function of experience? A systematic review and meta-analysis.

Novice drivers are statistically over-represented in reported road crashes, with recent evidence suggesting that some of this increased crash involvement may be a result of limitations in their cognitive processing. Such processing has typically been measured by recording drivers' patterns of eye movements, however, the exact ways in which eye movements are reported and interpreted varies substantially between different studies in the literature. Therefore, the objective of this systematic review was to investigate whether novice drivers and experienced drivers do differ in clear and reproducible ways in their visual search.

Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate-Lowering Response-In Search of a Minimum Effective Oxypurinol Concentration.

The aims of this study were to determine factors that predict serum urate (SU) lowering response to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum therapeutic oxypurinol concentration. Data from 129 participants in a 24-month open, randomized, controlled, parallel-group, comparative clinical trial were analyzed. Allopurinol dose, SU, and plasma oxypurinol concentrations were available at multiple time points.

"I can see you; I can feel it; and vice-versa": consciousness and its relation to emotional physiology.

In this paper, we explore whether masked emotional faces can elicit changes in physiology without awareness. We also explore whether emotional miss-discrimination involves the physiological correlates associated with the perception of an emotion. We adjust the discrimination threshold of presentation per participant and stimulus type to chance-level performance using hit rates and receiver-operating characteristics (ROC).

The unconscious mind: From classical theoretical controversy to controversial contemporary research and a practical illustration of the "error of our ways".

In this manuscript, the authors present an overview of the history, an account of the theoretical and methodological controversy, and an illustration of contemporary and revised methods for the exploration of unconscious processing. Initially we discuss historical approaches relating to unconsciousness that are, arguably, defamed and considered extraneous to contemporary psychological research. We support that awareness of the history of the current subject is pedagogically essential to understand the transition to empirical research and the reasons for which the current area is still so contentious among contemporary psychologists.

Comparing drivers' visual attention at Junctions in Real and Simulated Environments.

Driving simulation is widely used to answer important applied research questions, however, it is vital for specific driving tasks to undergo appropriate behavioural validation testing. Many previous validation studies have used simple driving tasks and measured relatively low-level vehicle control. The purpose of the current study was to investigate whether drivers' visual attention at intersections with different levels of demand, are similar in the simulator and on the road.