Time-domain brain: temporal mechanisms for brain functions using time-delay nets, holographic processes, radio communications, and emergent oscillatory sequences.

Time is essential for understanding the brain. A temporal theory for realizing major brain functions (e.g.

Time Is of the Essence: Neural Codes, Synchronies, Oscillations, Architectures.

Time is of the essence in how neural codes, synchronies, and oscillations might function in encoding, representation, transmission, integration, storage, and retrieval of information in brains. This Hypothesis and Theory article examines observed and possible relations between codes, synchronies, oscillations, and types of neural networks they require. Toward reverse-engineering informational functions in brains, prospective, alternative neural architectures incorporating principles from radio modulation and demodulation, active reverberant circuits, distributed content-addressable memory, signal-signal time-domain correlation and convolution operations, spike-correlation-based holography, and self-organizing, autoencoding anticipatory systems are outlined.

Noise edge pitch and models of pitch perception.

Monaural noise edge pitch (NEP) is evoked by a broadband noise with a sharp falling edge in the power spectrum. The pitch is heard near the spectral edge frequency but shifted slightly into the frequency region of the noise. Thus, the pitch of a lowpass (LP) noise is matched by a pure tone typically 2%-5% below the edge, whereas the pitch of highpass (HP) noise is matched a comparable amount above the edge.

A roadmap for the study of conscious audition and its neural basis.

How and which aspects of neural activity give rise to subjective perceptual experience-i.e. conscious perception-is a fundamental question of neuroscience.

Synchrony capture filterbank: auditory-inspired signal processing for tracking individual frequency components in speech.

A processing scheme for speech signals is proposed that emulates synchrony capture in the auditory nerve. The role of stimulus-locked spike timing is important for representation of stimulus periodicity, low frequency spectrum, and spatial location. In synchrony capture, dominant single frequency components in each frequency region impress their time structures on temporal firing patterns of auditory nerve fibers with nearby characteristic frequencies (CFs).

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury.

Dorsal root injury results in substantial and often irreversible loss of sensory functions as a result of the limited regenerative capacity of sensory axons and the inhibitory barriers that prevent both axonal entry into and regeneration in the spinal cord. Here, we describe previously unknown effects of the growth factor artemin after crush injury of the dorsal spinal nerve roots in rats. Artemin not only promoted re-entry of multiple classes of sensory fibers into the spinal cord and re-establishment of synaptic function and simple behavior, but it also, surprisingly, promoted the recovery of complex behavior.

Neurophysiology and neuroanatomy of pitch perception: auditory cortex.

We present original results and review literature from the past fifty years that address the role of primate auditory cortex in the following perceptual capacities: (1) the ability to perceive small differences between the pitches of two successive tones; (2) the ability to perceive the sign (i.e., direction) of the pitch difference [higher (+) vs.

Encoding of pitch in the human brainstem is sensitive to language experience.

Neural processes underlying pitch perception at the level of the cerebral cortex are influenced by language experience. We investigated whether early, pre-attentive stages of pitch processing at the level of the human brainstem may also be influenced by language experience. The human frequency following response (FFR), reflecting sustained phase-locked activity in a population of neural elements, was used to measure activity within the rostral brainstem.

Temporal codes and computations for sensory representation and scene analysis.

This paper considers a space of possible temporal codes, surveys neurophysiological and psychological evidence for their use in nervous systems, and presents examples of neural timing networks that operate in the time-domain. Sensory qualities can be encoded temporally by means of two broad strategies: stimulus-driven temporal correlations (phase-locking) and stimulus-triggering of endogenous temporal response patterns. Evidence for stimulus-related spike timing patterns exists in nearly every sensory modality, and such information can be potentially utilized for representation of stimulus qualities, localization of sources, and perceptual grouping.

Human frequency-following response: representation of pitch contours in Chinese tones.

Auditory nerve single-unit population studies have demonstrated that phase-locking plays a dominant role in the neural encoding of both the spectrum and voice pitch of speech sounds. Phase-locked neural activity underlying the scalp-recorded human frequency-following response (FFR) has also been shown to encode certain spectral features of steady-state and time-variant speech sounds as well as pitch of several complex sounds that produce time-invariant pitch percepts. By extension, it was hypothesized that the human FFR may preserve pitch-relevant information for speech sounds that elicit time-variant as well as steady-state pitch percepts.

Extradimensional bypass.

We discuss the concept of extradimensional bypass as it was developed by the late theoretical biologist Michael Conrad. An evolving system that optimizes its performance by gradient ascent (hill climbing) can avoid being trapped in local maxima by increasing the effective dimensionality of its search space. Many local maxima may become saddle points in the higher dimensional space, such that gradient ascent can continue unimpeded.