Publications by authors named "Peter Buchan"
Article Synopsis
- LHRH agonists like triptorelin (T) help lower ovarian estrogen production in hormone-sensitive breast cancer, and combining them with aromatase inhibitors like exemestane (EX) may enhance this effect.
- A study randomized healthy premenopausal women to receive T with or without EX over 8 weeks to evaluate their impact on estrogen levels.
- Results showed that the combination of T and EX led to significantly lower levels of estradiol and estrone compared to T alone, suggesting potential benefits for breast cancer treatment without major safety concerns.
Purpose: Two studies were conducted to compare the pharmacokinetics and tolerability of exemestane in postmenopausal subjects with various degrees of impairment of hepatic or renal function with those in healthy postmenopausal subjects.
Methods: All subjects were postmenopausal females. In study 1, nine subjects had normal hepatic function (Child-Pugh grade A), and nine had moderately (grade B) and eight severely (grade C) impaired hepatic function.