Personalised exercise rehabilitation in cancer survivorship: Findings from a triage and referral feasibility study.

Purpose: Screening, triage and referral systems are proposed as efficient, needs-based models of cancer rehabilitation. This study aimed to evaluate the feasibility of the PERCS triage and referral system.

Methods: Utilising a pre-post design, the feasibility of PERCS was evaluated quantitatively in the context of a physiotherapy-led clinic for patients diagnosed with cancer during COVID-19.

Personalised exercise rehabilitation in cancer survivorship: the percs triage and referral system study protocol.

Background: To effectively embed exercise rehabilitation in cancer survivorship care, a co-ordinated system of acute and community exercise rehabilitation services, forming a stepped model of care, is recommended. Patients can be directed to the exercise rehabilitation service which best meets their needs through a system of assessment, triage and referral. Triage and referral systems are not yet widely applied in cancer survivorship practice and need to be evaluated in real-world contexts.

Modelling the Influence of Task Constraints on Goal Kicking Performance in Australian Rules Football.

Background: The primary aim of this study was to determine the influence of task constraints, from an ecological perspective, on goal kicking performance in Australian football. The secondary aim was to compare the applicability of three analysis techniques; logistic regression, a rule induction approach and conditional inference trees to achieve the primary aim. In this study, an ecological perspective has been applied to explore the impact of task constraints on shots on goal in the Australian Football League, such as shot type, field location and pressure.

Effects of lower limb light-weight wearable resistance on running biomechanics.

Wearable resistance allows individualized loading for sport specific movements and can lead to specific strength adaptations benefiting the athlete. The objective was to determine biomechanical changes during running with lower limb light-weight wearable resistance. Fourteen participants (age: 28 ± 4 years; height: 180 ± 8 cm; body mass: 77 ± 6 kg) wore shorts and calf sleeves of a compression suit allowing attachment of light loads.

Methodological Considerations for Furthering the Understanding of Constraints in Applied Sports.

Commonly classified as individual, task or environmental, constraints are boundaries which shape the emergence of functional movement solutions. In applied sport, an ongoing challenge is to improve the measurement, analysis and understanding of constraints to key stakeholders. Methodological considerations for furthering these pursuits should be centred around an interdisciplinary approach.

Applications of a working framework for the measurement of representative learning design in Australian football.

Representative learning design proposes that a training task should represent informational constraints present within a competitive environment. To assess the level of representativeness of a training task, the frequency and interaction of constraints should be measured. This study compared constraint interactions and their frequencies in training (match simulations and small sided games) with competition environments in elite Australian football.

Prevalence of interactions and influence of performance constraints on kick outcomes across Australian Football tiers: Implications for representative practice designs.

Representative learning design is a key feature of the theory of ecological dynamics, conceptualising how task constraints can be manipulated in training designs to help athletes self-regulate during their interactions with information-rich performance environments. Implementation of analytical methodologies can support representative designs of practice environments by practitioners recording how interacting constraints influence events, that emerge under performance conditions. To determine key task constraints on kicking skill performance, the extent to which interactions of constraints differ in prevalence and influence on kicking skills was investigated across competition tiers in Australian Football (AF).

The relationship between workplace psychosocial environment and retirement intentions and actual retirement: a systematic review.

Psychosocial work characteristics are potential determinants of retirement intentions and actual retirement. A systematic review was conducted of the influence of psychosocial work characteristics on retirement intentions and actual retirement among the general population. This did not include people who were known to be ill or receiving disability pension.

Ward round template: enhancing patient safety on ward rounds.

Introduction And Aims: Concerns had been raised at clinical governance regarding the safety of our inpatient ward rounds with particular reference to: documentation of clinical observations and National Early Warning Score (NEWS), compliance with Trust guidance for venous thromboembolism (VTE) risk assessment, antibiotic stewardship, palliative care and treatment escalation plans (TEP). This quality improvement project was conceived to ensure these parameters were considered and documented during the ward round, thereby improving patient care and safety. These parameters were based on Trust patient safety guidance and CQUIN targets.

Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus.

Objective: To examine the role of interferon regulatory factor 3 (IRF-3) in the regulation of interleukin-23 (IL-23) production in patients with systemic lupus erythematosus (SLE).

Methods: Bone marrow-derived macrophages were isolated from both wild-type and IRF3(-/-) C57BL/6 mice. These cells were stimulated with the Toll-like receptor 3 (TLR-3) agonist poly(I-C), and IL-23p19 cytokine levels were analyzed by enzyme-linked immunosorbent assay.

Intracavity parametric generation of nanosecond terahertz radiation using quasi-phase-matching.

We report the use of quasi-phase-matching techniques based on periodically-poled MgO:LiNbO(3) for the generation of nanosecond duration pulses of terahertz radiation in intracavity optical parametric oscillators. Multiple idler-waves are generated with temporal studies indicating that the initiating process is the expected parametric down-conversion, but followed by cascaded difference frequency generation. A number of grating geometries have been explored, revealing the presence of dual solutions for the quasi-phase-matching process in the general case.

Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V.

Single cysteine mutants of calmodulin, Cam(S38C) and Cam(N111C), have been specifically labelled with Alexa488 maleimide to study the effects of calcium on the structural dynamics of calmodulin complexed with IQ3, IQ4 and IQ34 target peptide motifs of mouse unconventional myosin-V. Using phase fluorometry, the time-resolved anisotropy shows well-separated global and segmental correlation times. The calcium-sensitive global motion of either calmodulin domain can be independently monitored in domain-specific interactions of either apo- or Ca(4).