Voltage-gated sodium channels, sodium transport and progression of solid tumours.

Sodium (Na) concentration in solid tumours of different origin is highly dysregulated, and this corresponds to the aberrant expression of Na transporters. In particular, the α subunits of voltage gated Na channels (VGSCs) raise intracellular Na concentration ([Na]) in malignant cells, which influences the progression of solid tumours, predominantly driving cancer cells towards a more aggressive and metastatic phenotype. Conversely, re-expression of VGSC β subunits in cancer cells can either enhance tumour progression or promote anti-tumourigenic properties.

Factors predicting Registered Nurses' intentions to leave their organization and profession: A job demands-resources framework.

Aims: To develop a comprehensive model of nursing turnover intention by examining the effects of job demands, job resources, personal demands and personal resources on burnout and work engagement and subsequently on the intention to leave the organization and profession.

Background: The ageing population and a growing prevalence of multimorbidity are placing increasing strain on an ageing nursing workforce. Solutions that address the anticipated nursing shortage should focus on reducing burnout and enhancing the engagement of Registered Nurses (RNs) to improve retention.

The impact of chronic wasting disease and its management on hunter perceptions, opinions, and behaviors in Alberta, Canada.

The goal of this analysis was to identify changes in hunting behavior, satisfaction, and perceptions of risk in the presence of chronic wasting disease (CWD). Hunters completed an Internet survey containing direct questions regarding the impacts of CWD and gathering information about real and hypothetical hunting trips. Overall, hunters were satisfied with CWD management, and although certain behaviors were altered, the perceived risk by hunters did not seem to be high.

Using expert judgments to understand spatial patterns of forest-based camping: a values-at-risk application.

Fire management agencies in Canada are mandated with protecting multiple forest values from wildfire. Deciding where to reduce fire hazard and how to allocate resources and fire suppression efforts requires an understanding of the values-at-risk from wildfire. The protection of recreation infrastructure is often assumed to provide adequate protection of recreation values.

The on-ranch economics of riparian zone cattle grazing management.

A simulation model of a cattle ranch based in southern Alberta, Canada was developed to evaluate the on-ranch economics of adopting different grazing management strategies to improve riparian grazing capacity in natural grass rangeland. Under low-cost scenarios, there are positive economic incentives to adopt strategies to maintain riparian zones that already have high grazing capacity. However, riparian zones that have declined to moderate or low grazing capacity may require additional economic incentives to encourage ranches to adopt more costly management strategies to improve the grazing capacity.