Publications by authors named "Peter Berki"

Article Synopsis
  • Acute brain slices are commonly used to study the central nervous system, but the impact of injury on microglial cells—the brain's immune system—remains unclear.
  • This study examines how microglial cells change over time and affect neuron function and network organization in these slices, showing that they respond to injury.
  • The findings indicate that microglia play a crucial role in maintaining neuronal network integrity, and their dysfunction leads to significant impairments in brain activity both in the lab and in living organisms.
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GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal (HS) cells.

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The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in which microglial NKCC1 was deleted. We show that microglial NKCC1 shapes both baseline and reactive microglia morphology, process recruitment to the site of injury, and adaptation to changes in cellular volume in a cell-autonomous manner via regulating membrane conductance.

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In the present publication, multiwalled carbon nanotubes (MWCNT) coated with SiO-MgO nanoparticles were successfully fabricated via sol-gel method to facilitate their incorporation into polymer matrices. Magnesium acetate tetrahydrate and tetraethyl orthosilicate were used as precursors. The coated MWCNTs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and Raman spectroscopy methods.

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Ball milling method was used to fabricate successfully tin dioxide (SnO₂)/multi-walled carbon nanotubes nanocomposite materials using SnCl₂ ×2H₂O as precursor together with soda and salt as admixture. The as-prepared materials were characterized by transmission electron microscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Raman microscopy, and X-ray diffraction techniques. Observations revealed that applying both soda and salt are advantageous for increasing dispersity of tin dioxide nanoparticles on the surface of carbon nanotubes.

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