Digitally enabled asynchronous remote medical management of anxiety and depression: A cohort study.

Objective: To evaluate the clinical outcomes of a remote mental health program for managing anxiety and depression, primarily using asynchronous digital communication.

Methods: This retrospective cohort study examined U.S.

Characteristics and Symptoms of App Users Seeking COVID-19-Related Digital Health Information and Remote Services: Retrospective Cohort Study.

Background: Patient-facing digital health tools have been promoted to help patients manage concerns related to COVID-19 and to enable remote care and self-care during the COVID-19 pandemic. It has also been suggested that these tools can help further our understanding of the clinical characteristics of this new disease. However, there is limited information on the characteristics and use patterns of these tools in practice.

Development of a Visual Analytics Tool for Polytrauma Patients: Proof of Concept for a New Assessment Tool Using a Multiple Layer Sankey Diagram in a Single-Center Database.

Introduction: Early physiological assessment of multiple injured patients is crucial for decision making and has relied on personal experience of trauma experts. We have developed a new visual analytics tool (Sankey diagram, Watson Trauma Health care tool) that includes known prognostic parameters for polytrauma patients to help guide assessment and treatment decisions for physicians involved in trauma care.

Methods: A prospectively collected trauma database of a single level I trauma center (3655 patients) was used.

[Dialysis catheter placement in a persistent left-sided superior vena cava].

Persistent left-sided superior vena cava (PLSVC) is a central venous anomaly in up to 0.5% of the population. It is usually asymptomatic due to drainage into the right atrium via the coronary sinus.

A Data-Driven Decision-Support Tool for Population Health Policies.

Epidemiological models are key tools in assessing intervention policies for population health management. Statistical models, fitted with survey or health system data, can be combined with lab and field studies to provide reliable predictions of future population-level disease dynamics distributions and the effects of interventions. All too often, however, the end result of epidemiological modeling and cost-effectiveness studies is in the form of a report or journal paper.

Subclinical hypothyroidism: A common finding in adult patients with cyanotic congenital heart disease.

Objective: Cyanotic congenital heart disease is a systemic disease, with effects on multiple organ systems. A high prevalence of subclinical hypothyroidism (SCH) has been reported in a small cohort of cyanotic congenital heart disease patients. Subclinical hypothyroidism has been associated with various adverse cardiovascular effects, as well as an increased risk of progression to overt hypothyroidism.

Forensic Case Reports Presenting Immersion Pulmonary Edema as a Differential Diagnosis in Fatal Diving Accidents.

Immersion Pulmonary Edema (IPE) reduces the transport of gases over the respiratory membrane due to edema in the interstitium and respiratory zones. IPE has previously been described in both swimmers and divers, with a few known fatal cases. We have reviewed 42 SCUBA and snorkeling-related drowning deaths, and through a thorough analysis of each case, including both diving physiology and forensic pathology, we present IPE as a differential diagnosis to drowning in four cases.

Danish diving-related fatalities 1999-2012.

Aim: The purpose was to explore causative tendencies among diving fatalities to prevent similar injuries in the future.

Methods: We report 33 fatal diving injuries that occurred among Danish divers during the period 1999-2012 in Scandinavian waters. The study was performed as a retrospective overview.

OpenID Connect as a security service in cloud-based medical imaging systems.

The evolution of cloud computing is driving the next generation of medical imaging systems. However, privacy and security concerns have been consistently regarded as the major obstacles for adoption of cloud computing by healthcare domains. OpenID Connect, combining OpenID and OAuth together, is an emerging representational state transfer-based federated identity solution.

Implementation methods of medical image sharing for collaborative health care based on IHE XDS-I profile.

IHE XDS-I profile proposes an architecture model for cross-enterprise medical image sharing, but there are only a few clinical implementations reported. Here, we investigate three pilot studies based on the IHE XDS-I profile to see whether we can use this architecture as a foundation for image sharing solutions in a variety of health-care settings. The first pilot study was image sharing for cross-enterprise health care with federated integration, which was implemented in Huadong Hospital and Shanghai Sixth People's Hospital within the Shanghai Shen-Kang Hospital Management Center; the second pilot study was XDS-I-based patient-controlled image sharing solution, which was implemented by the Radiological Society of North America (RSNA) team in the USA; and the third pilot study was collaborative imaging diagnosis with electronic health-care record integration in regional health care, which was implemented in two districts in Shanghai.

Off the Radar: Comparative Evaluation of Radial Visualization Solutions for Composite Indicators.

A composite indicator (CI) is a measuring and benchmark tool used to capture multi-dimensional concepts, such as Information and Communication Technology (ICT) usage. Individual indicators are selected and combined to reflect a phenomena being measured. Visualization of a composite indicator is recommended as a tool to enable interested stakeholders, as well as the public audience, to better understand the indicator components and evolution over time.

CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate.

Stimulation of patients' immune systems for the treatment of solid tumors is an emerging therapeutic paradigm. The use of enriched autologous T cells for adoptive cell therapy or vaccination with antigen-loaded dendritic cells have shown clinical efficacy in melanoma and prostate cancer, respectively. However, the long-term effects of immune responses on selection and outgrowth of antigen-negative tumor cells in specific tumor types must be determined to understand and achieve long-term therapeutic effects.

Visual analytics for spatial clustering: using a heuristic approach for guided exploration.

We propose a novel approach of distance-based spatial clustering and contribute a heuristic computation of input parameters for guiding users in the search of interesting cluster constellations. We thereby combine computational geometry with interactive visualization into one coherent framework. Our approach entails displaying the results of the heuristics to users, as shown in Figure 1, providing a setting from which to start the exploration and data analysis.

Evaluation of irreversible compression ratios for medical images thin slice CT and update of Canadian Association of Radiologists (CAR) guidelines.

In June 2008, the Canadian Association of Radiologists published its Standards for Irreversible Compression in Digital Diagnostic Imaging within Radiology (Canadian Association of Radiologists 2012). The study suggested that at low levels of compression there was no difference in diagnostic accuracy between uncompressed JPEG and JPEG 2000. There were two exceptions; CT neurological and CT body images resulted in lower rating of image quality (Koff et al.

Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.

A major obstacle to efficacious T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivates tumor-infiltrating lymphocytes. In an autochthonous model of prostate cancer, we have previously shown that intratumoral injection of Ag-loaded dendritic cells (DCs) delays T cell tolerance induction as well as refunctionalizes already tolerized T cells in the tumor tissue. In this study, we have defined molecular interactions that mediate the effects of DCs.

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles.

Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of immune-modulating compounds into the synapse represents a major challenge. Here, we report that covalent coupling of maleimide-functionlized nanoparticles (NPs) to free thiol groups on T-cell membrane proteins enables efficient delivery of compounds into the T-cell synapse.

Automated Analytical Methods to Support Visual Exploration of High-Dimensional Data.

Visual exploration of multivariate data typically requires projection onto lower dimensional representations. The number of possible representations grows rapidly with the number of dimensions, and manual exploration quickly becomes ineffective or even unfeasible. This paper proposes automatic analysis methods to extract potentially relevant visual structures from a set of candidate visualizations.

User settings of cue thresholds for binary categorization decisions.

The output of binary cuing systems, such as alerts or alarms, depends on the threshold setting-a parameter that is often user-adjustable. However, it is unknown if users are able to adequately adjust thresholds and what information may help them to do so. Two experiments tested threshold settings for a binary classification task based on binary cues.

Spatiotemporal analysis of sensor logs using growth ring maps.

Spatiotemporal analysis of sensor logs is a challenging research field due to three facts: a) traditional two-dimensional maps do not support multiple events to occur at the same spatial location, b) three-dimensional solutions introduce ambiguity and are hard to navigate, and c) map distortions to solve the overlap problem are unfamiliar to most users. This paper introduces a novel approach to represent spatial data changing over time by plotting a number of non-overlapping pixels, close to the sensor positions in a map. Thereby, we encode the amount of time that a subject spent at a particular sensor to the number of plotted pixels.

Phenotypic and functional delineation of murine CX(3)CR1 monocyte-derived cells in ovarian cancer.

Ovarian tumor progression is marked by the peritoneal accumulation of leukocytes. Among these leukocytes, an immunosuppressive CD11b(+)CD11c(+) population has been identified in both human and ovarian tumors. The use of transplantable models of murine ovarian tumors has demonstrated that this population promotes ovarian tumor growth, whereas elimination of this population has been shown to inhibit ovarian tumor progression.

Pan-Canadian evaluation of irreversible compression ratios ("lossy" compression) for development of national guidelines.

New technological advancements including multislice CT scanners and functional MRI, have dramatically increased the size and number of digital images generated by medical imaging departments. Despite the fact that the cost of storage is dropping, the savings are largely surpassed by the increasing volume of data being generated. While local area network bandwidth within a hospital is adequate for timely access to imaging data, efficiently moving the data between institutions requires wide area network bandwidth, which has a limited availability at a national level.

Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression.

The predominant leukocyte population present in both human and murine peritoneal ovarian tumors is the Vascular Leukocyte (VLC). VLCs are recruited en masse to the ovarian tumor microenvironment whereupon they promote tumor progression. Importantly, the presence of VLCs is requisite for peritoneal ovarian cancer progression: selective elimination of VLCs inhibits tumor burden and ascites accumulation.

Informatics in radiology: image exchange: IHE and the evolution of image sharing.

The sharing of radiologic images has become a fundamental part of radiology services and is essential for delivering high-quality care. Film is quickly becoming obsolete as a means of transporting and sharing large volumes of imaging data. Image sharing has evolved from film to transportable media (eg, compact disks) to direct electronic exchange over the Internet.

Calreticulin requires an ancillary adjuvant for the induction of efficient cytotoxic T cell responses.

Molecular chaperones stimulate the immune system to induce both protective immune responses and therapeutic tumor rejection. However, the underlying basis for this immunogenic activity is not well understood. A variety of chaperones, including calreticulin, hsp70 and grp94, function as vehicles to efficiently traffic associated peptides into professional antigen presenting cells.