Repair of the philtrum: an illustrative case series.

Background: Distortion of the philtrum, which lends considerable symmetry to the midface, leads to a poor esthetic outcome.

Objective: This case series describes reconstructive approaches to six philtral defects after Mohs micrographic surgery. Reconstructive approaches including advancement flaps, full-thickness skin grafts, and second-intention healing are illustrated.

Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals.

The presence of certain types of human papillomavirus (HPV) is a known risk factor for the development of anogenital squamous cell carcinomas (SCCs). A similar association has been hypothesized for cutaneous SCCs, although, to our knowledge, no studies to date have combined sensitive HPV DNA detection techniques with epidemiologic data controlling for known risk factors to explore the association. We designed a case-control study examining HPV prevalence using highly sensitive PCR-detection assays in tissue samples from 85 immunocompetent patients with histologically confirmed SCCs and 95 age-matched individuals without a prior history of skin cancer.

Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up.

Objective: To assess the long-term cure rate for treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM) by means of a staged, margin-controlled, vertical-edged excision with rush permanent specimens and a radial sectioning technique.

Design: Retrospective follow-up study.

Setting: University-affiliated and private-practice dermatologic surgery clinics.