Using response to a standardized treatment to identify phenotypes for genetic studies of chronic rhinosinusitis.

Objectives: Studies of the genetics of chronic rhinosinusitis offer potential insights into the pathophysiology of this poorly understood condition. However, genetic studies are both expensive and time consuming-hence the importance of establishing beforehand the proper population and target genes. We wished to identify patient factors associated with a proposed definition of severe chronic rhinosinusitis to minimize heterogeneity and maximize the impact of genetic contributions.

Multimodal multidisciplinary surgical approach for the treatment of pituitary tumours.

Objectives: The surgical management of pituitary tumours is being impacted by the development of two key technologies: image guidance and endoscopy. This study sought to assess their impact.

Methods: Retrospective review of all patients referred to the Skull Base Clinic of the McGill University Health Centre since 2000.

Supracricoid laryngectomy outcomes: The Johns Hopkins experience.

Objective: To report the oncologic and functional results from our experience in performing supracricoid laryngectomy (SCL) for selected patients with laryngeal cancer.

Study Design: Retrospective chart review.

Methods: Twenty-four consecutive patients who underwent SCL for laryngeal cancer in our institution from December 2000 to March 2006 have been reviewed.

Complications of adenotonsillectomy revisited in a large pediatric case series.

Objective: To document the most important postoperative adenotonsillectomy morbidities, with an emphasis on prolonged hospitalization and readmissions.

Design: Retrospective chart analysis.

Methods: We reviewed 2067 cases of adenotonsillectomies performed at our institution over a period of 6 years.