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Publications by authors named "Peter A Stephens"

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Targeting the S and G2 checkpoint to treat cancer.
Tao Chen Peter A Stephens Fiona K Middleton Nicola J Curtin

Drug Discov Today

March 2012

Cell survival following DNA damage depends on activating checkpoints to arrest proliferation. Most cancer cells have dysregulated G1 checkpoints making them dependent on their S and G2 checkpoints, which are activated by ATR/Chk1 signalling. Thus, inhibiting ATR or Chk1 should selectively sensitise cancer cells to DNA damage.

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