Abnormal bilirubin binding to human serum albumin in a patient with unusual myeloma immunoglobulin G.

The binding of bilirubin was analysed in the serum of a patient with unusual myeloma. This patient presented an acquired Von Willebrand's disease due to the presence of a ternary complex formed by one molecule of myeloma immunoglobulin G and two molecules of albumin (Harlé et al. La Presse Médicale 19, 1661-1664 (1990)).

[Acquired von Willebrand's disease, cryoglobulinemia and pseudoanalbuminemia in monoclonal dysglobulinemia].

The authors report an exceptional case of complex monoclonal dysglobulinaemia characterized by cryoglobulinaemia, pseudoanalbuminaemia and acquired type 1 Von Willebrand's disease. All these biological abnormalities are consecutive to the formation of molecular complexes in vivo. These complexes have also been found in vitro between albumin immunoglobulins G.