Plasma cholesteryl ester fatty acids in 3- and 12-year-old Finnish children.

Risk factors associated with coronary heart disease were surveyed in a multicentre study carried out in 1979 among children living in different parts of Finland. The survey included analyses of plasma lipids and cholesteryl ester (CE) fatty acids as well as a dietary interview by a 48-hour recall method. The present report gives the plasma fatty acid compositions obtained from 181 3-year-old and 226 12-year-old children and their relations to dietary factors and other plasma lipids.

Radiation-related chronic heart disease.

Three cases of radiation-related chronic heart disease are reported. All three patients had been treated for Hodgkin's disease with a mantle technique six to ten years earlier. Ten years after radiation treatment, a 34-year-old woman had dyspnea during exercise.

Serum fatty acids in 8-year-old Finnish boys: correlations with qualitative dietary data and other serum lipids.

To survey risk factors in coronary heart disease in Finnish children, fasting serum specimens from 244 healthy 8-yr-old boys were analyzed for the fatty acid composition of cholesterol esters (CE), triglycerides (TG), free fatty acids (FFA), and phospholipids (PL). A qualitative dietary survey was made by asking parents to answer a questionnaire including, among others, a question on the kind of fat usually used on bread by the child. The mean percentages of linoleate (18:2) in serum cholesterol esters, triglycerides, free fatty acids, and phospholipids were 53.

Congenital central hypoventilation syndrome treated with diaphragm pacing.

Congenital central hypoventilation syndrome was diagnosed in an infant who since birth had shallow respiration and CO2 retention during sleep, absent ventilatory response to hypercarbia, and no underlying disease or trauma to account for the symptoms. Diaphragm pacing was started at the age of 8 1/2 months and has been successfully carried out at home, guided by end-tidal CO2 monitoring. After 22 months of home treatment, at the age of two years 9 months, linear growth and psychomotor development are progressing normally, while previous symptoms of cor pulmonale have not progressed.

Nutrient intake and blood lipids in children.

Nutrient intake and serum total cholesterol (C T), serum high density lipoprotein cholesterol (HLD), triglycerides (TG) and fatty acids were evaluated from 692 3-year, 8-year and 12-year-old children in different areas in Finland. Serum/plasma TC concentrations varied from 4.8 to 5.

Morphometry of coronary arteries: its use in children 1 year of age or older.

Coronary arteries from 52 children were cross-sectioned semiserially at 0.2-mm intervals. The sections that showed the greatest intimal thickening were chosen for morphometric analysis, which was performed with the aid of a coordinate digitizer.

Multicenter study of atherosclerosis precursors in Finnish children--pilot study of 8-year-old boys.

A multicentre study was launched to analyze the prevalence of risk factors for coronary heart disease and their determinants in Finnish infants, children and adolescents and to provide facts for the planning of intervention. The present report gives the results of the pilot study conducted among 264 8-year-old boys in 5 cities and corresponding rural areas in various parts of Finland. Data on eating habits were obtained from the parents by means of a questionnaire.

Endothelial cell damage in piglet coronary artery after intravenous administration of E. coli endotoxin. A scanning and transmission electron-microscopic study.

E. Coli endotoxin was administered to 6 piglets from a litter of 10. Three days after the endotoxin stimulus 3 piglets showed definitive morphological evidence of endothelial damage to their left coronary artery.

Fibromuscular dysplasia in a child: a generalized arterial disease.

After slight prodromal symptoms a fourteen-year-old girl had epileptic convulsions followed by a right-sided hemiplegia. Carotid angiogram showed almost total occlusion of the left arteria cerebri media. Six weeks later she developed elevated blood pressure followed by convulsions and lowered consciousness.

Coronary artery changes in newborn babies. A histological and electron microscopical study.

The main branch of the left coronary artery of 14 autopsied newborn babies was studied both in light and electron microscopy. Intimal and medial changes of varying severity were found in most cases. The lesions show edema and suggest insudation of the blood solutes into the vessel wall.

Double outlet right ventricle with extreme hypertrophy of muscle bundles associated with crista supraventricularis. A heart with three ventricles.

A baby born with cardiac, cerebral, ocular, palatal, renal and pulmonary anomalies died four hours after birth. The cardiac anomaly consisted of a double outlet right ventricle with extreme hypertrophy of the muscle bundles associated with the crista supraventricularis. The hypertrophic muscle mass divided the right ventricle into two parts, one of them corresponding to the outflow tract of the pulmonary artery.

Thickenings in the coronary arteries in infancy as an indication of genetic factors in coronary heart disease.

In Finland, mortality from coronary heart disease is high, and much higher in the eastern than in the western countries. Both left and right coronary arteries of 141 children who died under one year of age at the Children's Hospital, University of Helsinki, were investigated. Thirty-two of these children formed a western and 41 an eastern group according to the birthplaces of their grandparents in Finland.