A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.

Germline CHEK2 pathogenic variants confer an increased risk of female breast cancer (FBC). Here we describe a recurrent germline intronic variant c.1009-118_1009-87delinsC, which showed a splice acceptor shift in RNA analysis, introducing a premature stop codon (p.

Inkjet-printed high-performance and mechanically flexible organic photodiodes for optical wireless communication.

Emerging areas such as the Internet of Things (IoT), wearable and wireless sensor networks require the implementation of optoelectronic devices that are cost-efficient, high-performing and capable of conforming to different surfaces. Organic semiconductors and their deposition via digital printing techniques have opened up new possibilities for optical devices that are particularly suitable for these innovative fields of application. In this work, we present the fabrication and characterization of high-performance organic photodiodes (OPDs) and their use as an optical receiver in an indoor visible light communication (VLC) system.

Experimental multi-user VLC system using non-orthogonal multi-band CAP modulation.

This paper provides experimental results for a multi-user visible light communications system using multi-band carrier-less amplitude and phase (m-CAP) modulation scheme. We optimize the system performance by adapting pulse shaping filter parameters, subcarrier spacing and allocating different baud rates to individual sub-bands called allocated m-CAP (Am-CAP). We show that a maximal system data rate of ∼468 Mb/s for four users can be supported while gaining higher flexibility for optimization and the same or lower computational complexity compared with the conventional m-CAP scheme.

Visible light communications: increasing data rates with polarization division multiplexing.

In this Letter, we propose a new configuration for visible light communication systems, which results in doubling of the data rate due to the use of polarization division multiplexing. As light-emitting diodes are unpolarized incoherent light sources, we isolate both the perpendicular and parallel modes for independent modulation. For the first time, to the best of our knowledge, we show that it is possible to transmit and successfully recover two separate orthogonal frequency division multiplexing (OFDM) signals on each polarization (pol-OFDM).

Mobile User Connectivity in Relay-Assisted Visible Light Communications.

In this paper, we investigate relay-assisted visible light communications (VLC) where a mobile user acts as a relay and forwards data from a transmitter to the end mobile user. We analyse the utilization of the amplify-and-forward (AF) and decode-and-forward (DF) relaying schemes. The focus of the paper is on analysis of the behavior of the mobile user acting as a relay while considering a realistic locations of the receivers and transmitters on a standard mobile phone, more specifically with two photodetectors on both sides of a mobile phone and a transmitting LED array located upright.

Experimental verification of long-term evolution radio transmissions over dual-polarization combined fiber and free-space optics optical infrastructures.

This paper describes the experimental verification of the utilization of long-term evolution radio over fiber (RoF) and radio over free space optics (RoFSO) systems using dual-polarization signals for cloud radio access network applications determining the specific utilization limits. A number of free space optics configurations are proposed and investigated under different atmospheric turbulence regimes in order to recommend the best setup configuration. We show that the performance of the proposed link, based on the combination of RoF and RoFSO for 64 QAM at 2.

Domestic estimated breeding values and genomic enhanced breeding values of bulls in comparison with their foreign genomic enhanced breeding values.

Estimated breeding values (EBVs) and genomic enhanced breeding values (GEBVs) for milk production of young genotyped Holstein bulls were predicted using a conventional BLUP - Animal Model, a method fitting regression coefficients for loci (RRBLUP), a method utilizing the realized genomic relationship matrix (GBLUP), by a single-step procedure (ssGBLUP) and by a one-step blending procedure. Information sources for prediction were the nation-wide database of domestic Czech production records in the first lactation combined with deregressed proofs (DRP) from Interbull files (August 2013) and domestic test-day (TD) records for the first three lactations. Data from 2627 genotyped bulls were used, of which 2189 were already proven under domestic conditions.

Experimental verification of an all-optical dual-hop 10 Gbit/s free-space optics link under turbulence regimes.

This Letter presents original measurement results from an all-optical 10 Gbit/s free-space optics (FSO) relay link involving two FSO links and an all-optical switch. Considering the fact that reported analyses of relay links are dominated by analytical findings, the experimental results represent a vital resource for evaluating the performance of relay FSO links in the presence of atmospheric turbulence. Bit-error-rate (BER) performance of the relay system is tested for single and dual-hop links under several turbulence regimes.

Genetic variances of SNP loci for milk yield in dairy cattle.

Regression coefficients and genetic variances for 40,890 single nucleotide polymorphisms (SNPs) for milk yield were calculated using mixed model equations, with deregressed proof (DRP) as the dependent variable. Bulls were genotyped using the Illumina BovineSNP50 v2 BeadChip and SNPs were edited according the minor allele frequency (MAF) and high incidence of missing genotype. Evaluation was conducted in two rounds.