Unlocking the potential: How does technological innovation shape inclusive wealth? Empirical insights from top seven emerging economies.

Amidst the pursuit of sustainable development and economic prosperity, there has been growing criticism directed towards traditional metrics such as GDP because of their narrow focus on societal well-being and environmental considerations. Therefore, our study shifts its focus from GDP to a more comprehensive measure of wealth, known as inclusive wealth. Our objective is to investigate how technology contributes to the advancement of inclusive wealth encompassing produced, natural, and human capital.

Preparation, characterization and evaluation of HPβCD-PTX/PHB nanoparticles for pH-responsive, cytotoxic and apoptotic properties.

Paclitaxel (PTX) is a potent anticancer drug. However, PTX exhibits extremely poor solubility in aqueous solution along with severe side effects. Therefore, in this study, an inclusion complex was prepared between PTX and hydroxypropyl-β-cyclodextrin (HPβCD) by solvent evaporation to enhance the drug's solubility.

Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin-conjugated silver nanoparticles.

Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions such as cancer, ageing, and hypertension. Silk sericin (SS) is instrumental in cancer applications due to presence of flavonoids and carotenoids which are natural pigments, present in the layer of sericin that has antioxidant and antityrosinase activity. It reduces oxidative stress and suppresses cancer cytokines while interacting with reactive oxygen species (ROS) to stand against lipid peroxidation.

Nasopharyngeal myeloid sarcoma as a manifestation of acute monomyelocytic leukaemia.

This case report describes the case of a man in his seventies presenting with a nasopharyngeal deposit of myeloid sarcoma associated with acute monomyelocytic leukaemia. He presented with right nasal obstruction associated with unilateral pulsatile tinnitus. CT and MRI scans of sinuses identified a moderately restricting mucosal swelling of the right torus tubarius, and a biopsy of the lesion diagnosed a nasal deposit of myeloid sarcoma.

Role of renewable and non-renewable energy consumption in environmental quality and their subsequent effects on average temperature: an assessment of sustainable development goals in South Korea.

Environmental quality is a global concern, and an accurate assessment of environmental progress has emerged as a key element in achieving sustainable development goals. The study offers a two-pronged contribution by analyzing the interplay between renewable energy consumption, traditional energy consumption, and urbanization on environmental quality while simultaneously testing the impact of environmental quality on average temperature. Distinguishing itself from prior research, the study employs both carbon emissions and ecological footprint to ensure an intricate and reliable analysis.

A Pilot Standardized Simulation-Based Mechanical Ventilation Curriculum Targeting Pulmonary and Critical Care Medicine and Critical Care Medicine Fellows.

 The mastery of mechanical ventilation (MV) management is challenging, as it requires the integration of physiological and technological knowledge with critical thinking. Our aim was to create a standardized curriculum with assessment tools based on evidence-based practices to identify the skill deficit and improve knowledge in MV management.  For 3 years, 3 hours of standardized curriculum for each first-year pulmonary critical care medicine (PCCM) and critical care medicine (CCM) fellows was integrated into the orientation (chronologically): (1) a baseline knowledge pretest; (2) a 1-hour one-on-one case-based simulation session with debriefing.

Electrocardiogram changes as predictors for new imaging findings in repeat transthoracic echocardiography.

To determine if electrocardiogram (EKG) findings may be a useful tool to predict changes in repeat transthoracic echocardiogram (TTE). We evaluated patients who underwent TTE during hospitalization and their EKGs, and whether findings differed between studies. Of 229 hospitalized patients who underwent repeat TTE, 183 (80%) were abnormal.

Comparison of intranasal medication delivery devices before and after functional endoscopic sinus surgery using Phacon sinus surgery models.

Objective: Functional endoscopic sinus surgery for chronic rhinosinusitis improves sinus drainage and intranasal medication delivery. This study compares medication delivery with commonly used devices in normal and altered anatomy (post functional endoscopic sinus surgery) using sinus surgery models (Phacon).

Methods: Medication delivery was simulated via nasal drops, nasal spray and an irrigation device (Neilmed Sinus Rinse).

Advanced treatment strategies in breast cancer: A comprehensive mechanistic review.

Breast cancer is a destructive lump type that affects women globally. Despite the availability of multi-directional therapeutic strategies, advanced stages of breast cancer are difficult to treat and impose major healthcare burdens. This situation reinforces the need to identify new potential therapeutic compounds with better clinical features.

Anticancer genes (NOXA, PAR-4, TRAIL) are de-regulated in breast cancer patients and can be targeted by using a ribosomal inactivating plant protein (riproximin).

Background: Anticancer genes are an endogenous defense against transformed cells as they impose antineoplastic effects upon ectopic expression. Profiling the expression of these genes is fundamental for exploring their prognostic and therapeutic relevance in cancers. Natural compounds can upregulate anticancer genes in malignant cells and thus be useful for therapeutic purposes.

Same-Day Discharge After Left Bundle Area Pacing.

Background: Left bundle area pacing (LBAP) has emerged as an area that appears to be an attractive alternative to other forms of physiological pacing owing to its ease and favorable pacing parameters. Same-day discharge after conventional pacemakers, implantable cardioverter defibrillators, and more recently leadless pacemakers have become routine, especially after the COVID-19 pandemic. With the advent of LBAP, the safety and feasibility of same-day discharge remain unclear.

The role of telephone clinics in ENT.

Objective: This quality improvement project assessed the outcomes of telephone consultations for ENT patients in order to identify areas where telephone consultations may be useful in the long term.

Method: New ENT patient appointments in May 2019 and May 2020 were reviewed. Total outcomes as well as subspecialty-specific and presentation-specific outcomes were compared for telephone versus face-to-face consultations.

Apoptotic and antiproliferative effects of silk protein sericin conjugated-AgNO nanoparticles in human breast cancer cells.

silk sericin is a globular-like protein that is used as an antioxidant, antibacterial, and antitumor agent. In this current research, we isolated sericin by degumming process and formation of sericin-AgNO NPs confirmed by UV-vis spectra, SEM, EDX, FTIR, and XRD patterns. The sericin and sericin-AgNO NPs mediated changes in human breast cancer cells were determined.

Impact of Wire Sensor Location on Coronary Physiological Measurement.

Background: The location of the wire sensor to measure fractional flow reserve (FFR) and diastolic pressure ratio (dPR) has not been systematically studied. Therefore, we hypothesize that the coronary physiological measurements will vary with the location of the sensor.

Methods: Fifty-four patients were screened, and 30 consecutive patients were enrolled.

Expression profiling of anticancer genes in colorectal cancer patients and their in vitro induction by riproximin, a ribosomal inactivating plant protein.

Background: Ectopic expression of anticancer genes (ACGs) imposes antineoplastic effects on transformed cells. Clinically, reduced expression of these genes has been linked with poor prognosis, metastasis and chemo/radiotherapy resistance in cancers. Identifying expression pattern of ACGs is crucial to establish their prognostic and therapeutic relevance in colorectal cancer (CRC).

Immobilization and phytoavailability of antimony (Sb) in contaminated agricultural soils amended with composted manure.

A pot experiment was conducted to assess the Sb phytoavailability and its accumulation in the wheat before and after remediation, using the composted manure of poultry and sheep, and a chemical amendment (limestone). The present study evaluates the effects of amendments on Sb bioavailability in different soils and investigates the relationship between bioaccumulated Sb and its availability in spiked soils using two different single extraction methods. Furthermore, a sequential extraction procedure was used to measure different fractions of Sb in soil, in order to assess the effect of remediation.

Uroprotective and Hepatoprotective Potential of against the Experimental Animal Model.

() belonging to the family is traditionally used for liver and kidney diseases. The aim of the study was to evaluate the uroprotective and hepatoprotective potentials of in cyclophosphamide-induced interstitial cystitis and paracetamol-induced hepatotoxicity rat model, respectively. Nociception, bladder weight, vesical vascular permeability, Gray's criteria for edema and hemorrhage, and levels of nitric oxide, catalase, and glutathione were estimated and studied in the cystitis model.

Validating LA/AIDS model in the food market of Pakistan.

The study aims to conduct a consumer demand analysis of the food market of Pakistan by estimating its own price and cross-price elasticities. This study also examines expenditure and income elasticities to show the influence of relative change in price, total expenditure, and income on the relative change in demanded quantities of the selected food products. The study takes meat, vegetables, fruits, and pulses as different food baskets and estimates income elasticities, including uncompensated (Marshallian) and compensated (Hicksian) own price and cross-price elasticities.

Urdu Translation and Linguistic Validation of the Bladder Cancer Index Questionnaire.

Background This study aimed to translate the Bladder Cancer Index (BCI) questionnaire to Urdu and validate it to assess the quality of life of patients with bladder cancer. Material and methods After forward and backward translation of the BCI questionnaire into Urdu, content validity was calculated using the content validity index (CVI) based on input from five health experts regarding the clarity and relevance of the questionnaire. Construct validity was measured by comparing the inter-scale domains and subdomains of BCI and by comparing BCI with Short Form 36 (SF-36) using correlations.

Utility of Post-ureteroscopy Lesion Scale (PULS) in Per-operative Decision-Making for the Need of Double J Stent.

Objectives: To assess the applicability of the post ureteroscopy lesion scale (PULS) as an objective measure to define the need for double J (DJ) stent placement after ureterorenoscopy (URS).

Methods: Between June and December 2020 a cross-sectional study was conducted at a university hospital. All patients fulfilling the inclusion criteria undergoing URS for renal or ureteric stones were included.