Genetic and lifestyle risk factors for advanced liver disease among men and women.

Background And Aim: Liver disease is traditionally categorized as alcoholic and non-alcoholic. We studied various risk factors predictive of advanced non-viral liver disease in general population and analyzed the interaction between these factors and alcohol consumption.

Methods: Persons without underlying liver disease who participated in the Health2000 or FINRISK studies 1992-2012 comprised a cohort of 41 260 individuals.

Noncholesterol Sterols as Surrogate Markers in Patients with Severe Alcoholic Hepatitis.

Severe alcoholic hepatitis (AH) is a life-threatening condition lacking good serologic markers to tailor treatment and predict recovery. We examined the cholesterol metabolism in severe AH to explore prognostic markers and evaluate the profile of cholesterol precursors, cholestanol and phytosterols, in this context. We assessed serum cholesterol, cholesterol precursors, cholestanol, phytosterols, and biochemical markers in 24 patients with severe AH treated with prednisolone and randomized to ciprofloxacin in the ratio 1:1.

Incidence, survival and cause-specific mortality in alcoholic liver disease: a population-based cohort study.

Objective: We studied the incidence of severe ALD requiring hospitalization in Finland, and survival and causes of death among the ALD patients.

Methods: A cohort of 11,873 persons (8796 men and 3077 women) with diagnosis of ALD during the years 1996-2012 was identified from Finnish national Inpatient Register. The annual incidence of alcoholic hepatitis (AH) and alcoholic liver cirrhosis was calculated.

Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996-2013.

Both alcohol abuse and liver cirrhosis are known risk factors for various cancers. This article was aimed to assess the long-term risk of malignancies among patients with severe alcoholic liver disease (ALD), i.e.