THE FIRST REPORT OF LAPAROSCOPIC RADICAL CYSTECTOMY IN GEORGIA.

Bladder cancer is the ninth most commonly diagnosed malignant tumor worldwide. Radical cystectomy is the standard surgical treatment for non-metastatic, muscle-invasive bladder cancer and a recommended treatment of choice in a subset of highest-risk patients with non-muscle invasive disease. Recently, laparoscopic radical cystectomy has become an attractive alternative to an open counterpart and many centers worldwide have reported their early experiences with the technique.

Metastasis of renal cell carcinoma to contralateral adrenal gland: case report and review of the literature.

Isolated metastasis of renal cell carcinoma (RCC) to the contralateral adrenal gland is a rare complication occurring in 2.5% of cases. The optimal diagnosis and treatment of this condition is not well defined.

The value of nephron-sparing surgery for the treatment of renal cell carcinoma 4 to 7 cm in size.

Nephron-sparing surgery (NSS) is a treatment of choice for renal cell carcinoma (RCC) less than 4 cm. in size. However its efficacy in the treatment of RCC from 4cm to 7 cm is not well defined and is still controversial.

Treatment of renal cell carcinoma in pregnancy: simultaneous nephron-sparing surgery and Caesarian section (case report).

We present a case of a 33-year-old pregnant woman with renal cell carcinoma diagnosed at 24 weeks of gestational age. Simultaneous nephron sparing surgery (NSS) and Caesarean section (CS) was performed at 33 weeks of gestation. The successful cases of radical nephrectomy performed in pregnancy have been reported earlier however, we believe this is the first case of NSS and CS performed simultaneously.

Immunoreactivity of p27(Kip1), cyclin D3, and Ki67 in conventional renal cell carcinoma.

The goal of the study was to evaluate expression of the cell-cycle regulatory proteins (p27(Kip1) and cyclin D3) and proliferation marker Ki67 in normal human kidneys and renal cell carcinoma (RCC) tissues. Intensity of the markers' expression was prospectively studied and compared between normal and RCC tissue samples. Association was analyzed with cancer clinical parameters.

Expression of p27((Kip1)), cyclin D3 and Ki67 in BPH, prostate cancer and hormone-treated prostate cancer cells.

p27((Kip1)), cyclin D3 and Ki67 are the markers of DNA damage and cell proliferation. The goal of the current study was to analyze expression of the markers in benign and malignant prostate cancer tissues. Activity of p27((Kip1)), cyclin D3 and Ki67 was immunohistochemically evaluated in different cells of BPH, prostate cancer (PCa) and hormonally treated prostate cancer (HTPCa) tissues.

Down-regulation of p27(Kip 1) cyclin-dependent kinase inhibitor in prostate cancer: distinct expression in various prostate cells associating with tumor stage and grades.

The goal of the study was to analyze the expression of p27(Kip 1) cyclin-dependent kinase inhibitor protein (CDKI) in different cells of benign, malignant and hormonally treated prostate cancer tissue and assess their possible association with different clinical parameters. Expression of p27(Kip 1) CDKI was evaluated and compared in: 32 BPH, 20 prostate cancer (PCa) and 6 hormonally treated prostate cancer (HTPCa) tissues. Intensity of the expression was compared between the groups and association was soughed with the cancer clinical parameters.

Prognostic significance of p27(Kip 1) expression in renal cell carcinoma.

The importance of cyclin-dependent kinase inhibitor genes (CDKIG) in benign and malignant urological diseases is a subject of intense ongoing investigation. The goal of the current study was to analyze the expression of p27(Kip 1) CDKIG in benign and malignant renal cells and assess their possible association with different clinical parameters. Expression of p27(Kip 1) CDKIG was evaluated and compared in 24 normal human kidneys and in 46 renal cell carcinoma (RCC) samples.

Loss of p27(Kip1) CDKI is a predictor of poor recurrence-free and cancer-specific survival in patients with renal cancer.

The importance of cyclin-dependent kinase inhibitors (CDKI) in benign and malignant urological diseases is a subject of intense ongoing investigation. The goal of the current study was to analyze the expression of p27((Kip1))CDKI in benign and malignant renal cells and assess their possible association with different clinical parameters. Expression of p27((Kip1)) was evaluated and compared in 24 normal human kidneys and in 52 renal cell carcinoma (RCC) tissue samples.

Long-term results of simple enucleation for the treatment of small renal cell carcinoma.

Objective: We have analyzed our institutional experience with simple enucleation for the treatment of small renal tumors for elective indications.

Materials And Methods: A total of 30 patients underwent elective nephron-sparing surgery (NSS) from May 1997 to January 2001. All patients underwent NSS by means of enucleation.

Surgical management of renal cell carcinoma invading the inferior vena cava.

The aim of the study was the evaluation of long-term outcome and prognosis of the patients with renal cell carcinoma (RCC) extending into the inferior vena cava (IVC). Influence of the patient, tumor characteristics and therapeutic interventions on the disease prognosis was also assessed. 24 patients (19 male and 5 female) with RCC extending into the IVC underwent surgical treatment at our institution between 1990 and 2002.

Prostate cancer detection rate in patients with obstructive voiding symptoms by sextant biopsy: preliminary results.

To evaluate the effectiveness of a laterally directed sextant biopsy in the group of high volume prostate patients with obstructive voiding symptoms and suspected of prostate cancer. Biopsy was performed in 197 men (age: median 63 years, range 47 to 82 years) because of elevated PSA and/or abnormality in digital rectal examinations (DRE). In most cases, a markedly enlarged prostate was noted: the mean prostate volume was 79,9+/-38,5 cc, and in 73% of the cases, the volume of the prostate was >50 cc.

Right colonic reservoir with submucosally embedded tapered ileum--'Tiflis pouch'.

Seventeen patients with invasive bladder cancer aged between 44 and 67 years underwent radical cystectomy and construction of the continent urinary reservoir from 20 to 25 cm cecoascendum reconfigurated a.m. Heineke-Mikulicz.