Publications by authors named "Perry B Molinoff"
Article Synopsis
- Mitofusins (MFN1 and MFN2) are crucial mitochondrial proteins that facilitate mitochondrial fusion through structural changes and GTP hydrolysis, with MFN2 mutations linked to an untreatable condition called Charcot-Marie-Tooth disease type 2A (CMT2A).
- Researchers used small molecule activators to enhance MFN2 function, studying their effects on mitochondrial fusion and movement in both lab settings and in CMT2A mouse models, discovering that MFN2's GTPase activity and conformational changes are essential yet independent processes.
- The study demonstrated that both daily and sustained mitofusin activation effectively reversed neuromuscular decline in mice, suggesting potential
Catalepsy and changes in striatal and limbic dopamine metabolism were investigated in mice after oral administration of aripiprazole, haloperidol, and risperidone. Catalepsy duration decreased with chronic (21 day) aripiprazole compared with acute (single dose) treatment across a wide dose range, whereas catalepsy duration persisted with chronic haloperidol treatment. At the time of maximal catalepsy, acute aripiprazole did not alter neostriatal dopamine metabolite/dopamine ratios or homovanillic acid (HVA) levels, and produced small increases in dihydroxyphenylacetic acid (DOPAC).
View Article and Find Full Text PDFAripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed typical and atypical antipsychotics. Aripiprazole displays properties of an agonist and antagonist in animal models of dopaminergic hypoactivity and hyperactivity, respectively. This study examined the interactions of aripiprazole with a single population of human D2 receptors to clarify further its pharmacologic properties.
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